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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Valproic acid can cause muscle damage and liver issues, which improve after stopping the drug.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Some curcumin-like compounds can effectively and safely block the enzyme linked to hair loss and other conditions related to male hormones.

UK medical students lack dermatology education, liver biopsy patients with risk factors show more fibrosis, and certain fungi resist drugs due to melanin; genetics may influence female hair loss.

Phthirusa pyrifolia extract may lower testosterone and harm male rat reproduction without damaging the liver or kidneys.

A plant mixture extract helped grow hair by boosting cell growth and growth factors while blocking a hair loss-related enzyme.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

PAD3 plays a key role in hair and skin protein structure and may be linked to skin diseases.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Taking zinc supplements can help improve or cure hair loss caused by zinc deficiency.

Rice bran extract might help prevent hair loss.

Ficus carica extract improved fertility in rats and may help with certain health conditions.

Anti-androgens are safe and effective for treating moderate to severe adult female acne.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Isotretinoin is safe and effective for acne, with common side effects like dry lips; serious side effects are rare.

The new CoQ10 gel protects mouse skin better against aging from UV light than the old gel.

Some blood-thinning medications can increase the risk of bleeding, and certain factors like genetics and other health conditions affect their safety and effectiveness.

Long-term use of seizure medications can disrupt calcium metabolism, but this can be treated with vitamin D or UV light and does not affect seizure control.

Melatonin may benefit skin health and could be a promising treatment in dermatology.