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Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Experts recommend thorough medical, sexual, and psychosocial assessments for women's sexual dysfunctions, and suggest individualized treatment plans with regular check-ups. They also mention potential use of estrogen and androgen therapy, but with caution due to safety concerns.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Stem cell niches support, regulate, and coordinate stem cell functions.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

Cepharanthine, a Japanese hair loss drug, shows promise as a COVID-19 treatment but needs more testing.

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.