research The Developing Immune Network in Human Prenatal Skin
Human prenatal skin develops an immune network early on that helps with skin formation and healing without scarring.
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research Response of Alopecia Areata of the Beard to Oral Tofacitinib
Oral tofacitinib is a promising treatment for beard hair loss in alopecia areata.
research Rodent Models in Placental Research: Implications for Fetal Origins of Adult Disease
Using rodents for research shows that health problems in the womb can cause diseases later in life.
research Determination of Rat 5α-Reductase Type 1 Isozyme Activity and Its Inhibition by Novel Steroidal Oxazolines
New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.
research Azathioprine for the Treatment of Extensive Forms of Alopecia Areata: A Systematic Review
Azathioprine may help treat severe alopecia areata, but more research is needed.
research Lean Women with Polycystic Ovary Syndrome
PCOS in lean women is a serious health condition with implications beyond fertility, affecting metabolism and increasing cardiovascular disease risk.
research Nutraceuticals for Hormonal Imbalance Management
Nutraceuticals can effectively manage hormonal imbalances and related health issues.
research Clinical Features and Presentation of Polycystic Ovary Syndrome
PCOS is a hormonal disorder causing symptoms like excess hair, acne, irregular periods, and fertility issues.
research Metabolic Aspects of Polycystic Ovary Syndrome
Women with PCOS often have insulin resistance, abnormal lipid levels, and a higher risk of diabetes and heart disease; lifestyle changes and medication like metformin can help manage these risks.
research History and Physical Examination of Polycystic Ovary Syndrome: Detecting Too Much or Too Little
The document concludes that careful history and physical exams are crucial for accurately diagnosing polycystic ovary syndrome and distinguishing it from other similar conditions.
research Finasteride in the Treatment of Female Androgenic Alopecia
Finasteride may help postmenopausal women with hair loss but is not effective for all and should be used cautiously in premenopausal women.
research Severe Insulin Resistance in a Pediatric Patient: Key Areas to Address in Screening
The case emphasizes the need for careful screening in children for insulin resistance and related conditions.
research A Supplementary Report on the Toxic Manifestations of CHOP Regimen in Subjects with Intermediate Grade Non-Hodgkin's Lymphoma
CHOP chemotherapy causes many side effects but is generally well tolerated.
research Retinoids: Best Solutions for Acne
Retinoids are effective for acne but can cause serious side effects.
research Nutritional Therapy Versus 6-Mercaptopurine as Maintenance Therapy in Patients with Crohn's Disease
Elental is a good long-term treatment for Crohn's disease, similar to 6-mercaptopurine but with fewer side effects.
research GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects
GLP-1 receptor agonists, like Dulaglutide, Liraglutide, and Semaglutide, have potential benefits beyond the pancreas, including neuroprotection, pain suppression, cardiovascular protection, obesity management, and cancer treatment, but there are concerns about pancreatitis and pancreatic cancer risks.
research Early Clinical Expressions of Insulin Resistance: The Real Enemy to Look For
Recognizing and treating early signs of insulin resistance can help prevent type 2 diabetes and improve life quality.
research Long-Term Satisfaction and Tolerability with Low-Dose Flutamide: A 20-Year Surveillance Study on 120 Hyperandrogenic Women
Low-dose flutamide improved hirsutism and satisfaction in women but had common side effects, causing some to stop treatment.
research Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study
Women with Polycystic Ovary Syndrome are more likely to have Non-Alcoholic Fatty Pancreas Disease, which is associated with older age, metabolic syndrome, insulin resistance, and high male hormone levels.
research Insulin Resistance as a Risk Factor for the Development of Type 2 Diabetes Mellitus: A Systematic Approach
Insulin resistance increases the risk of developing type 2 diabetes and other health issues.
research Insulin Resistance Syndrome: The Sensitive IRS
Insulin resistance is linked to many health problems and is influenced by diet, genetics, and other factors.
research Clinical Aspects of the Metabolic Syndrome
Losing weight and eating better are key to managing metabolic syndrome and its related conditions.
research Metabolic Aspects of Polycystic Ovary Syndrome
Women with PCOS often have metabolic issues like insulin resistance and a higher risk of diabetes and abnormal lipid levels.
research Mycophenolate Mofetil as an Alternative Treatment for Autoimmune Hepatitis
Mycophenolate mofetil can effectively treat autoimmune hepatitis when standard drugs fail.
research Fatty Acid Composition of Selected Organs of Gerbils Maintained on a Fat-Deficient or Fat-Supplemented Diet
Gerbils on a fat-deficient diet had altered fatty acid levels, hair loss, reduced sperm, and lower body weight.
research Commonly Encountered Symptoms and Their Management in Patients With Cirrhosis
Cirrhosis affects quality of life with various symptoms, requiring a holistic, multidisciplinary approach for management.
research Studies on Lysosomes—XIII: Effects of Stilbamidine and Hydroxystilbamidine on Lysosomal Enzyme Release in Rabbit Liver
Stilbamidine and hydroxystilbamidine inhibit enzyme release from lysosomes and have effects similar to cortisol and chloroquine.
research Acquired Zinc Deficiency Dermatosis in Humans
Zinc supplements can resolve skin issues caused by zinc deficiency.
research Metabolite Screening of Aromatic Amine Hair Dyes Using In Vitro Hepatic Models
The study investigated the potential oxidative metabolism of nine aromatic amine compounds used in hair dyes using human liver microsomes and hepatocytes. Toluene-2,5-diamine (TDA), p-aminophenol, m-aminophenol, p-methylaminophenol, N,N'-bis(2-hydroxyethyl)-p-phenylenediamine, and 1-hydroxyethyl-4,5-diaminopyrazole showed no oxidative metabolism. While oxidized metabolites of 4-amino-2-hydroxytoluene (AHT), 2-methyl-5-hydroxyethylaminophenol (MHEAP), and phenyl methyl pyrazolone (PMP) were detected, they did not exhibit NADPH-dependent covalent binding, indicating they were not reactive. Further studies in human hepatocytes showed conjugation but no oxidative metabolites for AHT, MHEAP, PMP, and TDA. The findings suggested that the tested hair dye ingredients did not undergo hepatic metabolism to form potentially reactive oxidized metabolites.
research Clinical Evaluation of Postoperative Pressure-Induced Alopecia Using a Hand-Held Dermatoscope
A hand-held dermatoscope helped differentiate between pressure-induced alopecia and alopecia areata in a young patient, who then experienced hair regrowth within a month.