6 citations
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January 2022 in “BIO-PROTOCOL” This article provides a protocol for live imaging of C. elegans germline stem cells, highlighting their potential for studying mitosis and other cell processes, but does not report new experimental findings.
305 citations
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June 2012 in “Nature” This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.
23 citations
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March 2023 in “eLife” This study reveals that epidermal stem cell differentiation in mice involves dynamic transcriptional changes, with Keratin-10 transcription preceding gradual chromatin compaction shifts associated with differentiation.
December 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” The conclusion is that the dermal papilla is crucial for hair follicle regrowth, and hair follicles undergo significant structural changes in addition to cell division during regeneration.
This study found that in live mouse epidermal stem cells, chromatin compaction is heterogenous and reflects differentiation status, with transcriptional changes largely preceding chromatin rearrangements during differentiation.
October 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Scientists used a special imaging technique to observe that hair follicle regeneration involves cell division and structural changes, mostly in the lower part of the follicle, and that the dermal papilla at the base is crucial for regrowth.
This study reported a new method enabling the observation of the full leg regeneration process in the crustacean *Parhyale hawaiensis* over 10 days, capturing cellular resolution while minimizing photodamage, through innovative imaging techniques and computer-assisted cell tracking.
In this study, researchers developed a method for high-resolution live imaging of leg regeneration in the crustacean Parhyale hawaiensis, which effectively captures the entire process at cellular resolution over 10 days while minimizing photodamage.
1 citations
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February 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study describes a new imaging platform for the adult Drosophila midgut, facilitating real-time observation of cell behaviors and dynamics involved in organ renewal.
October 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reports that fly blood progenitors in a long-term organ culture model undergo symmetric cell divisions influenced by cell size and orientation, with infection triggering changes in cell differentiation kinetics.
This review discusses the dynamic behavior of immune cells in skin immune responses using intravital imaging in mice and reports no new clinical results.
January 2026 in “Inflammation and Regeneration” This review highlights that two-photon excitation microscopy is a valuable tool for visualizing live skin structures and immune responses at high resolution, though its clinical use is hindered by safety and cost issues.
37 citations
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July 2016 in “Current Opinion in Cell Biology” This review summarizes recent discoveries about how tissue-resident stem cells interact with their environments during normal conditions and after injury, without reporting new results.
July 2016 in “Cancer research” This study found that mutant cells in hair follicles can be tolerated or eliminated by surrounding normal tissue, suggesting the potential for wild-type cells to counteract oncogenic mutations.
April 2021 in “Journal of Investigative Dermatology” In this study, researchers observed that different ERK signal activation dynamics during hair follicle regeneration are linked to cell fate specification and are affected by distinct upstream signaling pathways.
28 citations
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February 2019 in “Genes” This review discusses the regulation and dynamics of the Wnt/β-catenin signaling pathway in development, pluripotency, and cancer, highlighting potential mechanisms and future research directions, but reports no new results.
9 citations
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January 2017 in “Elsevier eBooks” This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.
24 citations
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May 2016 in “Stem Cell Reviews and Reports” This article reviews the roles and mechanisms of stem and progenitor cell migration in adult organs for tissue homeostasis and regenerative medicine, but reports no new experimental results.
17 citations
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December 2014 in “Cell Stem Cell” This discussion explores advances in intravital imaging for visualizing stem cells, highlighting key discoveries and potential future developments; it reports no new experimental results.
31 citations
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May 2015 in “Stem Cell Reports” This research discusses a novel imaging approach in live mice to study stem cell and niche interactions in tissue homeostasis and reports no new results.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study provided a dynamic 4D atlas showing the development process of mouse hair follicles through a telescope-like model, revealing new insights into the origin of hair follicle stem cells.
In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, with both epithelial and neural components exhibiting dynamic remodeling, highlighting intricate epithelial-neural interactions in maintaining homeostasis.
16 citations
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September 2016 in “Experimental Dermatology” This review provides guidance on using two-photon microscopy for real-time and long-term visualization of stem cell activity in live mice skin, focusing on its application in researching skin and stem cell biology.
10 citations
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November 2019 in “Cold Spring Harbor Perspectives in Biology” This review discusses how recent advances in live imaging have revealed the dynamic and adaptable nature of stem cells during various biological processes, and reports no clinical results.
1 citations
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May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers developed a custom-designed 3D-printed microscope stage insert for inverted confocal microscopes, enhancing the accessibility of long-term intravital imaging of live cell dynamics in live transgenic mice, particularly in the skin.
6 citations
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June 2024 in “Scientific Reports” This study introduced RoPod, a customizable tool for low-stress live imaging of Arabidopsis roots, which improves data reproducibility and provides new insights into plant autophagy by revealing detailed, cell type-specific responses to chemical modulators.
3 citations
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March 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This review explores the advantages and limitations of using zebrafish models to study various skin diseases, but reports no new experimental results.
4 citations
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May 2023 in “Plastic & Reconstructive Surgery” This study found that transplanting adipose tissue into the rat dorsum supported long-term skin expansion by enhancing thickness, vascularization, and cell proliferation, with adipose-derived cells actively contributing to skin regeneration and growth factor expression.
May 2018 in “Journal of Investigative Dermatology” Activating Wnt in skin cells controls the number of hair follicles by directing cell movement and fate.
9 citations
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June 2017 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study suggests that local skin inflammation may enhance the deposition of autoantibodies in the skin, potentially affecting the severity of pemphigus lesions in mice.