341 citations
,
November 2009 in “The FASEB Journal” This article reviews the multifunctional roles of calreticulin outside the ER and highlights its impact on wound healing in animal models, but reports no new clinical results.
150 citations
,
December 2012 in “EMBO Reports” This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.
49 citations
,
January 2018 in “Theranostics” This study found that a novel skin patch combining extracellular matrix and ciprofloxacin promotes advanced wound healing and skin regeneration in mouse models of infected wounds.
43 citations
,
August 2016 in “Scientific Reports” This animal study found that Cinnamomi cortex water extract reduced prostate weight and improved histological changes in a benign prostatic hyperplasia model, suggesting potential as a treatment.
43 citations
,
October 2013 in “Journal of Investigative Dermatology” This article reviews organotypic skin culture systems and their applications in dermatological research, highlighting their ability to model human epidermal conditions in vitro, but it reports no new clinical results.
33 citations
,
December 2012 in “NMR in Biomedicine” This study reports that microencapsulation of therapeutic cells with contrast agents enables visualization across multiple imaging modalities, potentially improving cellular immunoprotection and tracking after transplantation.
30 citations
,
March 2017 in “PLoS ONE” In this study, adding δ34S isotope analysis to models modestly improved precision in estimating grizzly bears' salmon and terrestrial diets, but contributed little new information.
20 citations
,
August 2015 in “International Journal of Molecular Medicine” This study found that human placental extract promoted hair growth and influenced cellular pathways in vitro and rat models, suggesting potential for future hair loss treatments.
20 citations
,
March 2005 in “Current Medicinal Chemistry” This study reports that newly synthesized steroidal trienones exhibit higher 5α-reductase inhibitory activity than dienones in various biological models, suggesting potential use in treating androgen-dependent diseases.
16 citations
,
December 2018 in “ACS Biomaterials Science & Engineering” This research found that a biodegradable fibrous membrane incorporating fibroblast-derived ECM accelerated wound healing and improved neovascularization in a mouse model.
12 citations
,
June 2013 in “The Prostate” This study found that dutasteride more effectively inhibited androgen receptor signaling and reduced cell growth compared to finasteride in prostate cancer cell models, with varying sensitivities across different cell lines.
7 citations
,
March 2021 in “Biology” This study found that silk fibroin/sodium alginate scaffolds seeded with dermal papilla cells may accelerate skin repair and hair follicle regeneration in a rat model.
6 citations
,
July 2021 in “Microbial biotechnology” This study found that combining LED yellow light with an engineered strain expressing CXCL12 improved wound healing and reduced inflammation in a mouse model of scald wounds.
2 citations
,
October 2017 in “Global Media and Communication” In this study, ads in leading Indian men's magazines featured more international brands and Caucasian models, while promoting a class-based global masculinity among upper-class urban Indian men.
1 citations
,
September 2025 in “Frontiers in Immunology” In this study, researchers using a Treg-specific HuR-deficient mouse model found that the RNA-binding protein HuR is crucial for stabilizing Foxp3 mRNA, affecting Treg function and immune regulation, with HuR disruption leading to impaired Foxp3 expression and potential autoimmune dysfunction.
February 2026 in “Scientific Reports” This preclinical study found that Mesenchymal Stem Cell-derived Conditioned Media formulations were safe and effective in rat and mouse models for treating chemotherapy- and radiation-induced oral mucositis, demonstrating improved tissue regeneration and healing, most notably at higher concentrations.
This study observed that exosomes derived from adipose-derived stem cells significantly enhanced bone marrow mesenchymal stem cell migration and osteogenesis, leading to improved bone regeneration in a rat model of calvarial defects.
This study presents a two-photon imaging method to visualize low-threshold mechanoreceptor axon terminals in live mouse forepaw skin, enabling repeated high-resolution imaging to study sensory circuits during development and adulthood.
January 2025 in “Open Medicine” This study found that high-concentration cell-free adipose extract effectively reduced collagen deposition and blood vessel formation in a rabbit ear model, showing promise for preventing and treating hypertrophic scars.
This study found that elastin-like recombinamer (ELR) wound dressings promote tissue regeneration and stability without rejection in ex vivo and in vivo models, indicating potential for hard-to-heal wound treatment.
291 citations
,
April 2010 in “Gastroenterology” This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.
218 citations
,
January 2013 in “The Lancet Oncology” This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.
182 citations
,
June 2017 in “Biomaterials” This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.
42 citations
,
May 2013 in “Oral Diseases” Kennedy's disease leads to muscle weakness without a cure, but exercise and managing symptoms may help patients live a normal lifespan.
37 citations
,
January 2009 in “The Journal of Dermatology” In this study, hair follicle stem cells from ND-GFP transgenic mice were observed to be pluripotent, effectively repairing peripheral nerve and spinal cord injuries in mouse models.
30 citations
,
December 2017 in “Advanced Healthcare Materials” This study reports that using nanogel and layer-by-layer self-assembly to encapsulate single dermal papilla cells can form cell spheroids that regenerate hair follicles successfully in a hair follicle regeneration model.
27 citations
,
April 2018 in “Journal of autoimmunity” In this study, iNKT10 cells were found to play a significant role in preventing and treating alopecia areata in a humanized mouse model, suggesting these cells could have potential in managing related autoimmune disorders.
26 citations
,
December 2021 in “Regenerative Biomaterials” This study found that an injectable ceria-based nanocomposite hydrogel improved wound healing and epithelium regeneration, including hair follicle and adipocyte tissue formation, in full-thickness skin wound models.
18 citations
,
September 2020 in “International Journal of Nanomedicine” This study found that both allogeneic and xenogeneic small extracellular vesicles from adipose tissue similarly enhanced soft tissue regeneration and wound healing in rat models, implying similar therapeutic effects across species.
18 citations
,
August 2018 in “The FASEB journal” This study found that Hoxc13-/- rabbits exhibit complete hair loss on the head and dorsum, providing a potential model for understanding human ECTD-9 and related dermatological conditions.