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The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Human skin can make serotonin and melatonin.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The Rotterdam Study aims to understand various diseases in older adults.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

PGD2 stops hair growth and is higher in bald men with AGA.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Fungi-produced compounds can change plant root growth.

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Pectin biosynthesis is essential for the growth of cotton fibers and Arabidopsis root hairs.

Fibromodulin might help reduce scarring if increased in adult wounds like in fetal skin that heals without scars.

Women with PCOS face higher risks of diabetes and heart disease, and these risks increase with obesity.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Finasteride safely lowers DHT levels without affecting testosterone.

EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Turmeric may have benefits for skin health, but more research is needed to confirm its effectiveness.

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.

Women with PCOS are more than twice as likely to develop nonalcoholic fatty liver disease.

Cyproterone acetate-estrogen most effective for hirsutism, but consider side effects and patient needs.

Applying a special compound can promote hair growth without harmful side effects.

New micelle solutions greatly improve skin delivery of certain antifungal drugs.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.