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Polymeric nanohydrogels show potential for skin drug delivery but have concerns like toxicity and regulatory hurdles.

Stem cell therapies could be a promising alternative for hair loss treatment, but more research is needed to understand their full potential and safety.

More research is needed to understand how testosterone is maintained in adult males.

Minoxidil and finasteride treat hair loss; more research needed for other options.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

New treatments for male hypogonadism are effective and should be personalized.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Finasteride's solubility and bioavailability improved by forming solid dispersions and inclusion complexes.

New retinoids are effective for various skin conditions and are being developed to have fewer side effects.

Cyclodextrins improve finasteride's solubility and bioavailability for hair loss treatment.

Finasteride delivery through skin improved using invasomes and iontophoresis.

Nanocarriers like liposomes and cyclodextrins improve how angiotensin-(1-7) is delivered in the body.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Terbinafine quickly builds up in skin and hair, staying effective for over 3 weeks.

One minoxidil-sensitive potassium channel exists in human hair follicles.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.

Niosomes improve minoxidil skin penetration for hair loss treatment.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

Massage increases how deep both rigid and flexible liposomes can go into skin, with flexible ones going deeper, and covering the skin (occlusion) helps rigid ones more.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

New physical methods like electrical currents, ultrasound, and microneedles show promise for improving drug delivery through the skin.

Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.

Different factors like pH, gel type, and chemical enhancers affect how well hydrocortisone gets into hair follicles, and less hydrated skin doesn't work well with the test method.

Microparticles help caffeic acid stay longer in hair follicles for better treatment of folliculitis.

The flutamide-loaded hydrogel is a promising, skin-friendly treatment for acne and hair loss, potentially requiring less frequent application.

Topical therapies show promise for hair loss and acne treatment with minimal side effects.

Use some skin medications with caution during pregnancy; avoid strong steroids, certain eczema treatments, and systemic retinoids, but many topical treatments and nasal sprays are safe.

The polyherbal hair oil effectively reduces dandruff and promotes hair growth.