26 citations,
October 2021 in “Clinical, Cosmetic and Investigational Dermatology” The secretome from mesenchymal stem cells shows promise for treating skin conditions and improving skin and hair health, but more research is needed.
8 citations,
February 2022 in “Vascular Health and Risk Management” Some skin conditions may increase the risk of heart disease, and understanding their connection could lead to better treatments.
February 2024 in “Scientific reports” Four genes are potential markers for hair loss condition alopecia areata, linked to a specific type of cell death.
Hair follicles can be used to quickly assess drug effects in cancer treatment.
15 citations,
December 2021 in “Pharmaceutics” The study found key factors in the cause of hidradenitis suppurativa, its link to other diseases, and identified existing drugs that could potentially treat it.
November 2023 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium” SLICK cattle have better heat tolerance due to specific gene expression and pathway differences.
9 citations,
August 2021 in “Experimental dermatology” Hidradenitis suppurativa is a skin disease caused by the breakdown of the skin's natural immune barriers, especially around hair follicles.
L-PGDS has specific binding sites for its functions and could help in drug delivery system design.
1 citations,
November 2011 in “British journal of pharmacology” Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
20 citations,
June 2013 in “Journal of Lipid Research” The research explains how a human enzyme binds and processes its substrate, which could relate to its role in biological functions and hair loss.
5 citations,
July 2014 in “Acta Crystallographica Section D-biological Crystallography” Mutations in the enzyme don't significantly change how it binds to its specific substances.
96 citations,
December 2002 in “Experimental dermatology” NGAL indicates abnormal skin cell differentiation.
2 citations,
August 2019 in “Journal of Investigative Dermatology” Higher levels of the DP2 receptor may lead to hair loss.
18 citations,
June 2009 in “Medical Hypotheses” The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.
1 citations,
November 2015 in “Indian Journal of Clinical Biochemistry” The conference presented findings on how vitamin D levels, genetic factors, and lifestyle choices like smoking and yoga affect various health conditions and diseases.
10 citations,
August 2022 in “International Journal of Molecular Sciences” Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.
68 citations,
April 2013 in “Journal of Investigative Dermatology” Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.
124 citations,
July 2012 in “Archives of Dermatological Research” Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
68 citations,
May 2011 in “European Journal of Dermatology” Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.
66 citations,
January 2017 in “Acta dermato-venereologica” Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.
11 citations,
July 2017 in “Expert Opinion on Investigational Drugs” New hair loss treatments may include topical medications, injections, and improved transplant methods.
5 citations,
February 2013 in “Expert Review of Dermatology” New acne treatments include combination creams, advanced retinoids, and light therapies, focusing on safety and patient adherence.
3 citations,
February 2015 in “Protein Expression and Purification” Scientists successfully purified a protein called Wnt3a, which is involved in processes like hair growth, but the overall yield was low, suggesting more work is needed to improve this.
57 citations,
March 2014 in “Experimental Dermatology” Prostaglandin D₂ might be targeted for new male pattern baldness treatments.
21 citations,
November 2017 in “Scientific Reports” Different human hair follicle stem cells grow at different rates and respond differently to a baldness-related compound.
19 citations,
March 2007 in “Journal of diabetes science and technology” Rosiglitazone may be better than metformin for insulin resistance in PCOS, but more research is needed on certain biomarkers.
56 citations,
March 2016 in “International Wound Journal” Skin grafts are effective for chronic leg ulcers, especially autologous split-thickness grafts for venous ulcers, but more data is needed for diabetic ulcers.
50 citations,
January 2012 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids” Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.
24 citations,
November 2017 in “Prostaglandins & Other Lipid Mediators” CRTH2 antagonists might be useful for treating many conditions because they play a role in immune and inflammation responses.
23 citations,
June 2019 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.