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This study found that Cidea is critical for regulating lipid storage and sebum secretion in sebaceous glands, with its deficiency causing hair issues and impaired skin functions in mice.

Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.

This review highlights the limited research on sebocyte lipid droplets and their proteins despite their role in sebocyte differentiation and potential involvement in skin diseases like acne and alopecia, and reports no new results.

This study found that human meibomian glands differ significantly from free and hair-associated sebaceous glands in morphology and lipid composition, making them highly specialized holocrine glands.

This study demonstrates that Puerariae Lobatae Radix may regulate skin lipid metabolism by inhibiting sebaceous gland growth and reducing triglyceride secretion, highlighting its therapeutic potential for sebaceous gland-related conditions.

This study observed that the ethyl acetate extract of Equisetum debile showed high activity against 5α-reductase and lipid peroxidation with no cytotoxicity on dermal papilla cells.

This study suggests that ethyl acetate extract of Equisetum debile may be effective for functional food and nutraceutical use due to its strong 5α-reductase, IL-6 inhibition, and lipid peroxidation activities without cytotoxic effects.

This article reviews the aging process of sebaceous glands, highlighting the role of intrinsic and extrinsic factors on their degradation and reporting no new clinical findings.

This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.

This review discusses the effects of dietary protein and its components on cholesterol, essential fatty acids, and possible health consequences, but presents no new clinical findings.

This study found that inhibiting autophagy in mouse preputial glands alters lipid metabolism, delays aging-related duct changes, and reduces pheromone production, indicating autophagy's critical role in gland homeostasis and cell breakdown during secretion.

This study found that autophagy in the preputial glands of mice plays a crucial role in regulating lipid and fatty acid metabolism, as well as pheromone production.

In this study, it was observed that NIPAL4 mutations linked to autosomal recessive congenital ichthyosis lead to abnormal skin barrier function due to cytotoxic effects disrupting lipid structure and organization, which topical treatments only partially ameliorated.

This study found significant differences in cashmere fiber diameters between two groups of cashmere goats and identified 211 genes and 50 metabolites related to hair follicle growth and cellular functions, suggesting potential pathways to improve cashmere quality.

In this study, a topical application of Lotus corniculatus seed extract significantly reduced sebum production and skin oiliness in humans through inhibition of lipid synthesis pathways.

This study on Sdr16c5/Sdr16c6-null mice found that inactivating these genes significantly increased Meibomian gland secretions and altered lipid profiles but had a subtle impact on sebogenesis, suggesting the genes control a bifurcation point in meibogenesis pathways.

This study found that in mice, deleting the keratin 10 gene enhances sebocyte differentiation and increases secretion of sebum and certain lipids without affecting proliferation-associated keratins.

This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.

In this study, the researchers found that constitutive activation of the EGFR in mice led to increased sebum production, enlarged sebaceous glands, and altered gene expression related to sebocyte proliferation and lipogenesis.

In this study, researchers observed that phospholipid-calcium carbonate hybrid nanoparticles effectively delivered Tofacitinib citrate topically, which significantly inhibited hair follicle apoptosis and promoted hair growth in a mouse model of chemotherapy-induced alopecia, compared to a traditional Tofacitinib solution.

Solid Lipid Particle technology makes retinol more stable, effective, and gentle on the skin.

This study found that local androgen biosynthesis and metabolism in human sebaceous glands play a crucial role in sebum synthesis and secretion.

This study found that asebic mice exhibit abnormal sebaceous gland differentiation and insufficient sebum production due to defective regulation of cell processes, despite possessing normally developing sebaceous glands initially.

This review discusses the influence of androgens on hair and sebaceous growth, emphasizing that response may depend more on peripheral sensitivity than on hormone levels; it reports no new empirical results.

This article reviews androgen excess and cardiometabolic risks in women, highlighting increased cardiovascular disease risk in those with polycystic ovary syndrome, but reports no new clinical results.

This review discusses leptin's regulatory roles in the progression of various dermatological diseases and reports no new clinical results, highlighting a complex relationship still under investigation.

In this study, thymic stromal lymphopoietin (TSLP) induced IL-4/IL-13 from T cells, prompting sebum secretion and adipose loss, suggesting IL-4/IL-13 may affect skin barrier function in atopic dermatitis.

This review discusses the relationship between hyperandrogenism and insulin resistance in PCOS, focusing on insulin dynamics, molecular mechanisms, genetic studies, and potential long-term treatments, but presents no new clinical results.

This study found that while a nanostructured lipid carrier improved drug delivery in conventional skin models, excess sebaceous content hindered its effectiveness in targeting hair follicles.

This study found that the peptide derivative beta-Ala-Pro-Dab-NHbenzyl may reduce wrinkles and sebum production in human skin by inhibiting dipeptidyl peptidase 4, suggesting potential for acne and skin inflammation treatment.