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This study identified biallelic variants in the LSS gene as a possible genetic cause of palmoplantar keratoderma-congenital alopecia syndrome type 2, highlighting the role of cholesterol synthesis in skin cornification.

This review discusses natural remedies and nanoparticle formulations for alopecia management and reports no new clinical results, emphasizing potential benefits of herbal treatments over synthetic therapies.

This study demonstrates that DHT-induced lipid synthesis in sebocytes involves the mTOR pathway, suggesting mTOR inhibitors may help modulate androgen-dependent sebum overproduction.

This review discusses factors affecting hair health, types of alopecia, and the potential of phytochemicals in managing hair loss but reports no new clinical results; it highlights the need for further studies.

This symposium discussed the role of lipids, inflammation, and stem cells in cicatricial alopecia but reports no new research findings; it highlights lipid pathways as significant in these hair disorders.

Skin-associated cartilage cells can influence hair growth by altering specific signaling pathways.

In this study, bovine milk-derived oligosaccharides were found to increase sebocyte proliferation, lipid content, and inflammatory mediator synthesis through the mTORC1 pathway, potentially contributing to milk-based inflammation in sebocytes.

In this study, XZYFD, a Traditional Chinese Medicine formulation, was found to improve androgenetic alopecia in a testosterone-induced mouse model by promoting hair regrowth, restoring follicular morphology, and modulating androgen metabolism, MAPK signaling, and lipid metabolism pathways, suggesting potential benefits for patients with metabolic dysfunction.

This study highlights the ZmNF-YC1-ZmAPRG pathway as a potential mechanism to improve maize tolerance to phosphorus deficiency, emphasizing its role in modulating lipid and photosynthetic activity, although direct impacts on root adaptations remain unclear (Bai et al., 2024).

In this study, ALA-PDT significantly reduced lipogenesis in an acne-like model by upregulating OLR1 and suppressing lipid accumulation, highlighting a potential therapeutic target.

In this study, nitrogen starvation in Chlorella sp. FC2 IITG led to increased lipid accumulation by altering the expression of enzymes involved in various metabolic pathways, suggesting potential for genetic engineering of microalgae.

In this study, finasteride was found to reduce cholesterol levels and delay atherosclerosis in LDL receptor-deficient mice, and men using finasteride reported lower cholesterol levels, suggesting potential cardiovascular benefits by improving lipid profiles.

Hormones and signaling pathways control sebaceous gland function and could help treat acne.

This review highlights recent findings on the importance of signalling pathways in sebaceous gland morphogenesis and differentiation, but reports no new clinical results.

This study found significant changes in gene expression related to skin structure and signaling pathways in AEC syndrome skin, offering new insights into the syndrome's molecular underpinnings.

This study revealed that chronic restraint stress in mice led to significant alterations in metabolic pathways and gene expression associated with hair growth inhibition, using metabolomics and transcriptomics analyses.

In this study, researchers analyzed the skin proteome of Alpine Merino sheep to identify proteins and pathways related to wool fiber diameter, finding that cyclic adenosine monophosphate and certain signaling pathways may play a role in this trait.

This review discusses the roles of various PLA2 enzymes in skin health and disease, highlighting potential pathways for future diagnosis and therapy, but it reports no new clinical results.

AGC2-1 protein is essential for root hair growth in Arabidopsis.

In this study, researchers identified two mechanisms of lipid loss from hair when exposed to surfactants, with the mechanism depending on the lipid's hydrophobicity.

This study observed that inflammatory stimuli significantly altered gene expression in rat theca-interstitial cells, affecting pathways related to growth and androgen production, which are central features of polycystic ovary syndrome.

In this study, synchrotron-powered infrared microscopy revealed that hair follicles are a favored penetration pathway for cyanophenol and ethylhexyl methoxycinnamate in human skin, without altering protein secondary structure.

This study found that the protein Foxn1 is crucial for the development and fat-storing capacity of dermal white adipose tissue in mice, influencing both lipid metabolism and adipogenesis in the skin through Bmp2 and Igf2 signaling pathways.

The researchers reported that PPARβ/δ may influence the yak hair follicle cycle by modulating lipid metabolism in dermal papilla cells, with varying expression during different hair growth phases, affecting both lipid content and cell proliferation.

This study found that TGFβ signaling is essential for keeping sebocytes undifferentiated by reducing lipid-related gene expression, using a novel human sebocyte culture model.

This study found that glycyrrhetinic acid, derived from licorice, may help alleviate acne symptoms by regulating lipid synthesis and inflammatory responses through multiple pathways, as observed in both in vitro and in vivo settings.

This study found that clusters of mRNAs and lncRNAs in the peripheral blood of PCOS patients were aberrantly expressed, and certain lncRNA-mRNA pairs in the chemokine signaling pathway may be genetically related to PCOS.

This study identifies a polygenic basis for atypical recurrent flank alopecia in Cesky Fousek dogs through genome-wide association analysis and gene expression profiling, highlighting several metabolic pathways involved in the condition.

In this study, minoxidil-induced vasodilation in rat aorta was found to be mediated by ATP-sensitive potassium channels and nitric oxide pathways, but was not significantly altered by lipid emulsion pretreatment.

This study suggests that lipin-1 plays a crucial role in keratinocyte differentiation by modulating protein kinase C activity through diacylglycerol levels, with implications for skin biology.