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In this study, researchers developed topical tofacitinib-loaded cationic lipid nanoparticles, which improved absorption and targeted hair follicles in an ex vivo pig ear model, showing promise in treating alopecia areata by reducing symptoms through the JAK/STAT pathway.

This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.

This study found that using nanoporous silica entrapped lipid-drug complexes enhanced the solubility and bioavailability of dutasteride in beagle dogs.

This study found that niosomes significantly enhanced the skin deposition of retinoic acid while reducing its permeation, outperforming other tested nanoformulations.

This study found that nanostructured lipid carriers with clobetasol propionate significantly enhance follicular drug delivery compared to commercial cream, and manual massage further doubles follicular retention.

In this study, extracting internal lipids from Caucasian hair fibers led to decreased water permeability, influenced by the fluidity of lipids.

This study found that white hair fibers have lower lipid content and different water absorption dynamics compared to brown hair fibers, suggesting differences in their barrier functions.

This study found that high concentrations of dimethyl sulfoxide are needed to cause significant swelling in hair fibers, though the swelling is reversible, unlike the effects on skin.

This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.

This study found that serum levels of NF-L and GFAP decreased but tau protein levels did not change in anorexia nervosa patients after short-term partial weight restoration.

This research suggests that geometric classification of hair into fewer groups may be more reliable and useful for studying hair characteristics, rather than racial descriptions, especially in medical and forensic applications.

This review study focused on various in vitro methods to evaluate skin permeation and retention of sunscreens, highlighting the importance of assessing sunscreen penetration due to widespread nanomaterial usage and advancements in cosmetic formulation.

This review discusses the critical parameters for MALDI IMS sample preparation in skin analysis and highlights its applications in wound healing, neoplasia, and infection research, but reports no new clinical results.

Nanocarriers could improve how drugs are delivered through the skin but require more research to overcome challenges and ensure safety.

This review discusses various nanoparticles used to enhance skin permeation and target delivery to skin organelles, but reports no new experimental results.

This study presents a method for directly measuring the solubility of solid chemicals in the skin's stratum corneum under various humidity conditions, emphasizing its importance for dermal drug delivery and chemical safety assessments.

This study found that diffusion coefficients of chemicals in artificial sebum are significantly higher than those in stratum corneum lipids, suggesting the hair follicle may significantly contribute to transdermal permeation.

Dr. Jia-You Fang is a highly experienced researcher in drug delivery and related fields, with numerous publications and international collaborations.

This study highlights that solid lipid nanoparticles may improve the absorption and bioavailability of poorly soluble drugs, offering advantages over conventional formulations for various administration routes.

This research reported that squarticles, nanoparticles made from sebum-derived lipids, enhanced the follicular delivery and skin accumulation of diphencyprone and minoxidil, indicating effective drug deposition with reduced systemic absorption in alopecia treatment.

This review examines advancements in lipid and inorganic nanocarriers, such as liposomes and inorganic nanoparticles, for transdermal drug delivery, noting enhanced absorption and stability but acknowledging that few have reached clinical use.

This review discusses the potential for surface-modified nanostructured lipid carriers to enhance hair regrowth by improving drug absorption and stability, focusing on their use with agents like minoxidil and finasteride for hair loss treatment.

This study found that retinoic acid and a retinol complex formulation showed different permeation and compound localization in a skin equivalent model, with unique lipid changes observed with only the retinol formulation.

This study found that a topical formulation with nanostructured lipid carriers containing finasteride significantly restored hair follicles in androgenetic alopecia-induced rats without systemic absorption, suggesting its potential for safer and effective AGA treatment.

This study evaluated enhancers to improve skin absorption of topical cetirizine for androgenic alopecia treatment and found eucalyptus and Tween 80 most effective, while propylene glycol had the weakest effect.

In this study, researchers investigated EGCG's spectroscopic properties and its interaction with DPPG lipid, finding that both experimental and theoretical approaches agree on the electronic transitions and reveal an increased absorbance due to molecular interactions.

This study found that combining laser ablation with nanoparticulate drug formulations effectively enhanced the skin and follicular delivery of hydrophilic drugs like minoxidil and minocycline in preclinical models.

This study observed that the molecular structure of keratins in hair fibres' discrete transition zone differs in breast cancer patients, with altered lipid ester absorption bands reverting post-cancer removal.

This study developed lipid-core nanocapsules for encapsulating menthol, improving its solubility and thermal stability, and demonstrated their safety and rapid skin absorption in ex vivo tests, highlighting potential applications for cosmeceuticals.

This study reports that ethosomal formulations, such as ethosomal acyclovir and minoxidil, improved therapeutic effectiveness by enhancing skin permeation, leading to faster healing of herpes labialis lesions and increased skin absorption compared to standard formulations.