June 2025 in “Indian Journal of Dermatology” This article reports a case of late onset linear and unilateral basaloid follicular hamartoma in an elderly male, highlighting the clinical presentation, histopathological findings, and planned treatment approach.
This chapter reviews when to perform linear-strip excision vs. follicular unit excision for hair loss surgery, noting their respective advantages and disadvantages, without presenting new clinical findings.
January 2025 in “Indian Journal of Paediatric Dermatology” This case report documents the youngest recorded instance of a linear variant of alopecia areata in a 4-year-old child, highlighting the uniqueness and rarity of this clinical presentation and noting its possible association with favorable prognosis, though further evidence is needed.
November 2023 in “Facial Plastic Surgery” This study discusses the advantages and disadvantages of two hair graft harvesting methods, strip follicular unit transplantation and follicular unit excision, highlighting their implications for creating effective surgical plans for hair restoration without providing specific new results.
October 2023 in “Facial Plastic Surgery” This review discusses combining follicular unit excision (FUE) and linear strip excision (LSE) donor harvesting methods to optimize graft yield while minimizing donor depletion, but provides no new clinical results.
August 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that a patient with rare linear lichen planopilaris experienced complete hair regrowth after 12 weeks of treatment with the antibody ixekizumab, suggesting it as a potential targeted therapy.
April 2023 in “Journal of Investigative Dermatology” In this study, a mouse model of scarring alopecia demonstrated significantly reduced CD200R expression in affected skin, which may contribute to immune attacks on hair follicles.
January 2022 in “Clinical Cases in Dermatology” This report describes a case of a 4-year-old boy diagnosed with linear alopecia areata, characterized by patchy hair loss and associated with unique hyperpigmented skin lesions.
April 2021 in “International Journal of Research in Dermatology” This case report describes a 7-year-old child with linear lupus panniculitis of the scalp, treated successfully with a combination of hydroxychloroquine, topical and intralesional steroids, and a topical calcineurin inhibitor.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” In this case report, a patient with early inflammatory linear morphea showed remarkable hair regrowth after treatment with topical creams, highlighting dermoscopy's value in diagnosis and monitoring disease progression.
May 2020 in “Hair transplant forum international” This article discusses linear morphea en coup de sabre and emphasizes the need for hair transplant surgeons to consider potential calvarial abnormalities when planning hair restoration, but it does not present new clinical results.
January 2016 in “Dermatology online journal” This case report describes an adolescent female with a linear array of trichoepitheliomas on her left neck, highlighting the clinical presentation of this benign tumor.
214 citations
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April 2017 in “Cell” This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.
159 citations
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September 2018 in “Journal of Investigative Dermatology” This study identified two cell surface markers, FAP and CD90, that distinguish between papillary and reticular fibroblasts in human skin, suggesting distinct functions and distribution in dermal layers.
69 citations
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August 2015 in “Stem Cells” This review discusses the principles, methods, advantages, and limitations of lineage tracing in stem cell and developmental biology but does not report new findings.
57 citations
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January 2014 in “Cold Spring Harbor Perspectives in Medicine” Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.
37 citations
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May 2021 in “Frontiers in Cell and Developmental Biology” This study found that Ng2+ perivascular cells in mouse skin are a diverse lineage-restricted population primarily recruited from papillary or reticular fibroblast lineages during wound healing, maintaining heterogeneity in both wounded and non-wounded skin.
17 citations
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March 2012 in “The Journal of Pathology” This article argues that lineage labeling with genetic markers is the gold standard for identifying epithelial stem cells, contrary to the view that in vitro methods alone are sufficient.
11 citations
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January 2013 in “Methods in molecular biology” This study describes a method for labeling and tracking hair follicle stem cells in mouse skin using a Cre/lox recombination system with tamoxifen, providing insights into stem cell behavior and contribution to tissue regeneration.
10 citations
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August 2023 in “The EMBO Journal” This study explored the epigenetic mechanisms of dermal fibroblast progenitor differentiation and found that the repressive chromatin profile from H3K27me3 prevents these progenitors from reforming skin in allograft assays, despite their multipotent potential.
4 citations
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March 2024 in “Developmental Dynamics” In this study, researchers used conditional mouse models to show that inactivation of the Alx4 gene in specific cell lineages leads to craniofacial and limb defects without affecting postnatal survival, providing insights into Alx4's role in development and disease.
4 citations
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May 2014 in “Biochemical Society Transactions” This review discusses environmental reprogramming and the plasticity of epithelial cells, emphasizing their potential for new cell therapy approaches; it reports no new experimental results.
1 citations
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March 2024 in “Science” In this study, researchers found that retinoic acid is crucial for hair follicle stem cell function and tissue regeneration by resolving lineage plasticity, with potential therapeutic implications for hair growth, wound healing, and cancer.
1 citations
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March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that Dermal Fibroblast Progenitors have repressed chromatin profiles which hinder their ability to reform skin in allograft assays despite their differentiation potential.
June 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study developed a comprehensive atlas of human scalp tissue to uncover cell states and lineages in hair follicles, identifying disease-specific cellular changes associated with non-scarring and scarring hair loss, which may offer new diagnostic and therapeutic insights.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that the deletion of Med1 in dental epithelia causes a shift from dental to hair tissue development, suggesting the importance of Med1 in maintaining tissue-specific lineage.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrated that Tet2 and Tet3 enzymes are crucial for controlling gene expression related to hair differentiation in mice, suggesting DNA demethylation could be a new method for managing hair growth.
23 citations
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December 1991 in “Annals of the New York Academy of Sciences” This study reported that human balding scalp grafted onto nude mice showed reduced linear growth rates of both vellus and terminal hairs.
15 citations
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April 1970 in “PubMed” This letter describes a case of a 22-year-old woman with ichthyosis serpentina and related symptoms, suggesting it as a variant form of ichthyosis associated with bamboo hair, without necessarily including atopic features.
12 citations
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September 2000 in “Journal of the European Academy of Dermatology and Venereology” This study found that balneophototherapy improved skin lesions in a 13-year-old with severe ichthyosis linearis circumflexa, but regular treatment is likely necessary to maintain remission.