66 citations
,
December 2014 in “Nature Communications” Fibroblasts can be turned into melanocytes for potential skin treatments.
58 citations
,
November 1969 in “British Journal of Dermatology” This report describes two patients with ichthyosis linearis circumflexa exhibiting symptoms resembling Netherton's disease, noting multiple hair shaft defects and discussing a possible connection to aminoaciduria.
56 citations
,
October 2010 in “Pediatric Clinics of North America” This article discusses various types of epidermal nevi and associated syndromes but presents no new research findings.
39 citations
,
September 2007 in “BMC developmental biology” This study found that Neuregulin3 can influence the development and differentiation of mammary glands and epidermal features in mice, potentially by inducing c-Myc and altering cell proliferation and adhesion.
30 citations
,
February 2015 in “Anais Brasileiros de Dermatologia” This case report describes a 4-year-old boy with Netherton syndrome, where trichoscopy importantly aided diagnosis and is recommended for all children with erythroderma.
7 citations
,
October 2022 in “Development Growth & Differentiation” This review summarizes recent insights into the developmental origin and formation of tissue stem cells across various organs, reporting no new experimental results.
3 citations
,
June 2002 in “PubMed” This case report describes the diagnosis of Netherton's syndrome in two young sisters, attributing their serious erythrodermia, poor hair growth, and atopic conditions to this hereditary condition.
2 citations
,
November 2016 in “PubMed” This report describes the use of a robotic system in hair restoration surgeries, showing that it reduces physician fatigue and variability in graft extraction while achieving high patient satisfaction and rapid healing.
2 citations
,
June 2013 in “Journal of Dermatological Case Reports” This article presents a case of Olmsted syndrome in a 5-year-old boy, adding to the limited number of reported cases of this rare keratinization disorder.
March 2026 in “Journal of the American Academy of Dermatology” Hair diameter diversity could improve androgenetic alopecia assessment and treatment planning.
December 2025 in “Clinical Case Reports” In this study, researchers reported that dermoscopic examination of eyebrow hairs can help in the early diagnosis of Netherton syndrome in children by detecting trichorrhexis invaginata, facilitating prompt counseling and care while awaiting genetic test results.
October 2023 in “Indian Dermatology Online Journal” This case report describes a 1.5-month-old baby with Schimmelpenning-Feuerstein-Mims syndrome, manifested by skin and ocular abnormalities along with developmental delays and hearing loss observed later, highlighting the syndrome's progression and need for multidisciplinary management.
January 2022 in “Nasza Dermatologia Online” In this study, dermoscopy was suggested as a potentially useful tool for improving the clinical recognition of pilomatricoma.
July 2021 in “British Journal of Dermatology” Laser treatment for skin conditions VEN and ILVEN is effective and liked by patients.
October 2025 in “Indian Journal of Paediatric Dermatology” In this case report, a 6-year-old boy with Netherton syndrome was diagnosed using trichoscopy, which revealed characteristic hair shaft abnormalities such as bamboo, golf tee, and matchstick hairs.
May 2025 in “International Journal of Trichology” This case report highlights a 7-year-old boy with suspected Netherton syndrome who presented with itchy lesions, hair abnormalities, and elevated immunoglobulin E levels. The authors report complete resolution of symptoms with oral Acitretin after failed methotrexate treatment.
April 2017 in “IOSR journal of dental and medical sciences” This abstract discusses Netherton Syndrome, a genetic disorder with a characteristic triad of symptoms caused by SPINK5 gene mutation, and reports no new clinical findings or treatment advances.
301 citations
,
February 2019 in “Nature Communications” In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.
182 citations
,
May 2003 in “Development” This study found that Myc activation in mouse epidermis impairs keratinocyte adhesion and motility by downregulating extracellular matrix and cytoskeleton proteins, affecting hair lineage differentiation.
168 citations
,
August 2009 in “EMBO molecular medicine” This review discusses epidermal stem cell diversity, revealing previously unrecognized differences in stem cell populations, but reports no new experimental results; it highlights the need for further exploration of stem cell interactions and quiescence.
151 citations
,
February 2006 in “Stem Cells and Development” This study found that hair follicle-derived dermal stem cells and bone marrow mesenchymal stem cells have similar growth, differentiation capabilities, and surface marker expressions, suggesting hair follicles could be accessible sources for mesenchymal stem cells.
143 citations
,
May 2017 in “Nature cell biology” This study found that the transcription factor Gata6 regulates the sebaceous duct lineage identity and plays a crucial role in epidermal wound healing by enabling dedifferentiation and broader lineage capabilities in post-mitotic cells.
143 citations
,
September 2008 in “Experimental gerontology” This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
123 citations
,
January 2020 in “International Journal of Molecular Sciences” This review discusses the role of fibroblast heterogeneity in determining skin scarring versus regeneration and reports no new results, highlighting opportunities for developing antiscarring therapies.
107 citations
,
August 2012 in “Seminars in Cell & Developmental Biology” This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.
105 citations
,
October 2018 in “Nature” This study found that vismodegib promotes Basal cell carcinoma regression by inducing tumor differentiation but leaves a small population of quiescent cells that can drive relapse, which can be eliminated by adding a Wnt signaling inhibitor.
96 citations
,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.
80 citations
,
May 2011 in “Nature Cell Biology” This review discusses the progress in identifying stem cells responsible for tissue regeneration and highlights technological advances in tracking their behavior, but reports no new clinical results.
80 citations
,
September 2007 in “Cell Cycle” This study found that nestin-expressing cells in the hair follicle bulge exhibit multipotent stem cell-like properties and can generate neural cells both in vitro and in vivo.
70 citations
,
May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Notch signaling is crucial for maintaining proper melanocyte distribution and preventing premature differentiation in the melanocyte lineage within hair follicles.