26 citations
,
April 2019 in “Genes” In this study, researchers identified novel long non-coding RNAs related to cashmere fineness in goats, highlighting a potential regulatory network involving lncRNA XLOC_008679 and its target gene KRT35.
26 citations
,
January 2016 in “Annals of Dermatology” This study found that Ecklonia cava polyphenols increased human dermal papilla cell proliferation and extended hair shaft length in vitro and ex vivo, suggesting potential as a therapeutic candidate for hair loss.
26 citations
,
March 2015 in “Phytotherapy Research” This study found that forsythiaside-A, a natural compound from Forsythia suspensa, was more effective than finasteride at preventing apoptosis of hair cells and delaying the catagen phase entry in an androgenic alopecia mouse model.
26 citations
,
October 2007 in “Experimental Dermatology” This study found that l-carnitine stimulated hair growth in vitro by promoting proliferation and reducing apoptosis in human scalp hair follicles, suggesting potential as a treatment for hair loss.
25 citations
,
February 2019 in “Genomics” This study reports that milk goats exhibit significantly more differentially expressed genes related to hair follicle cycling across different months compared to cashmere goats, especially in December.
25 citations
,
April 2015 in “Journal of Investigative Dermatology” This study found that Gsdma3 mutation in mice allows hair follicles to bypass a typical telogen phase and directly enter the anagen phase, suggesting Gsdma3's role in hair cycle transitions by regulating Wnt signaling.
25 citations
,
January 2014 in “Annals of Dermatology” Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.
25 citations
,
March 2012 in “Journal of oncology pharmacy practice” This case report describes an elderly multiple myeloma patient whose hair repigmentation was associated with lenalidomide use, suggesting hair graying may be reversible.
25 citations
,
August 2010 in “Journal of Biological Chemistry” This study found that NFI-C plays a crucial role in the transition from the telogen to anagen phase of the hair follicle cycle, affecting hair growth initiation in mice.
25 citations
,
January 2002 in “Folia Pharmacologica Japonica” This article reviews the proposed mechanism of minoxidil in treating androgenetic alopecia, suggesting it may prolong the anagen phase by modulating cell growth factors and vascular activity, but reports no new results.
25 citations
,
March 2000 in “Journal of Endocrinological Investigation” Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.
24 citations
,
January 2020 in “International Journal of Molecular Sciences” This review discusses the potential benefits of flavonoid-containing botanicals, such as Panax ginseng, in reducing hair loss and promoting hair growth, but reports no new experimental results.
24 citations
,
March 2018 in “Pigment Cell & Melanoma Research” This review discusses the interactions between melanocyte stem cells and their niche in hair regeneration and repair, but reports no new results; recent studies on molecular pathways are highlighted.
24 citations
,
December 2014 in “International Journal of Molecular Medicine” In this study, researchers found that petroleum ether extract of Eclipta alba significantly stimulated follicular keratinocyte proliferation and reduced TGF-β1 expression in nude mice, suggesting potential use for certain types of alopecia.
23 citations
,
November 2020 in “Central-European Journal of Immunology/Central European Journal of Immunology” This review explores the autoimmune hypothesis of alopecia areata and the possible genetic and melanogenesis-associated autoantigens, but reports no new clinical findings.
23 citations
,
January 2018 in “Elsevier eBooks” This chapter reviews formulation principles for creating cosmetic nanoemulsions and applications targeting skin and hair care, but does not present new experimental results.
23 citations
,
June 2015 in “Journal of Tissue Engineering and Regenerative Medicine” This study demonstrated that a 3D air–liquid culture system using Wnt-CM-treated cells can induce hair regeneration in nude mice and may facilitate large-scale preparation for hair loss treatment.
22 citations
,
August 2009 in “Evidence-based Complementary and Alternative Medicine” This study found that a composition including Serenoa repens extract and anti-inflammatory agents effectively suppressed inflammation-related gene expression in a keratinocyte model, suggesting a potential dual strategy for treating androgenetic alopecia.
21 citations
,
March 2019 in “Experimental Dermatology” This review discusses the role of perifollicular macrophages in hair growth and suggests targeting them could be relevant for managing hair growth disorders, but reports no new results.
21 citations
,
November 2017 in “Archives of Dermatological Research” This study found that women with female pattern hair loss had increased 5α-reductase isozymes and decreased aromatase mRNA levels, potentially affecting their response to treatment.
21 citations
,
January 2015 in “Oncology Research and Treatment” This study found that sensor-controlled scalp cooling was effective in preventing hair loss during chemotherapy, particularly in premenopausal patients and those without systemic comorbidities or additional medications.
20 citations
,
December 2016 in “Neurodegenerative disease management” This study found that teriflunomide, an oral medication taken once daily, significantly slowed disability progression in patients with relapsing multiple sclerosis, supported by positive results in two Phase III trials and supplemented by various analyses including long-term studies and patient-reported outcomes.
20 citations
,
June 2010 in “Genes and Immunity” This study found distinct gene expression patterns in the blood of alopecia areata patients, suggesting involvement of immune processes and new pathways like Wnt signaling and apoptosis in disease pathogenesis.
20 citations
,
September 1978 in “International Journal of Dermatology” Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.
19 citations
,
August 2019 in “Expert Opinion on Therapeutic Targets” This review discusses emerging targets for developing drugs to treat hair loss and reports no new clinical results; the authors emphasize the potential for therapies that regenerate hair follicles.
19 citations
,
November 2018 in “Nutrients” This study reports that polyphenols from Annurca apples may safely promote hair growth and protect against chemotherapy-induced alopecia without interfering with chemotherapy regimens.
19 citations
,
July 2018 in “Mechanisms of Ageing and Development” This review examines how caloric restriction could promote autophagy to rejuvenate aging stem cells, though the precise molecular mechanisms remain unclear.
19 citations
,
December 2015 in “Journal of Materials Chemistry B” This study found that using layer-by-layer encapsulation techniques on dermal papilla cells can support their function and may help treat hair loss when used in conjunction with freshly isolated epidermal cells.
19 citations
,
April 2015 in “International Journal of Molecular Sciences” This study identified distinct gene expression patterns in wool follicle bulbs that may play important roles in wool follicle cycling and regeneration in sheep.
19 citations
,
April 2015 in “Developmental Dynamics” This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.