27 citations
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September 1988 in “PubMed” In this study, researchers used three-dimensional reconstruction to show that the shape of the hair follicle determines the hair's form, with variations observed among different racial groups.
24 citations
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January 2011 in “International Journal of Trichology” This review highlights the light microscopic features of various infectious and non-infectious hair conditions and reports no new clinical results.
12 citations
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July 2016 in “Forensic science international” This study found that postmortem root banding in hair is likely due to the degradation of the intermacrofibrillar matrix in the cortex, with no damage to the cuticle observed.
7 citations
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November 2013 in “Pediatric and Developmental Pathology” This retrospective review of hair samples from pediatric patients indicated that microscopic hair examination might be a useful first-line investigation for diagnosing various genetic conditions.
1 citations
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October 2022 in “Dermatology practical & conceptual” Isolated patchy heterochromia with pili annulati can occur without other health issues.
July 2026 in “Dermatology Practical & Conceptual” In this study, pediatric hair and scalp disorders were effectively diagnosed using trichoscopic and light microscopic examinations, demonstrating high agreement with clinical diagnoses and emphasizing their utility as reliable, non-invasive diagnostic tools in a hospital-based setting.
January 2019 in “Global Dermatology” This review discusses the genetic disorder, monilethrix, characterized by fragile, brittle hair and its inheritance patterns, and reports no new clinical results.
September 2016 in “Journal of Dermatological Science” Polarizing light microscopy can easily and reliably diagnose congenital keratinizing disorders like Netherton syndrome.
56 citations
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March 2017 in “Plant and Cell Physiology” This study used light sheet fluorescence microscopy to successfully image and analyze calcium oscillations in the root hairs of Arabidopsis thaliana, finding that these oscillations correlate with the root hair growth rate and that auxin affects these properties.
August 2018 in “Journal of Investigative Dermatology” This study found that combining optical clearing methods with light-sheet fluorescence microscopy allows detailed 3D visualization of normal and pathological human skin biopsies, revealing differences in epidermal thickness and volume.
June 2020 in “Journal of Investigative Dermatology” This study found that human hair follicle dermal papilla cells and keratinocytes self-assembled differently in 3D spheroid co-cultures, providing insights into cell distribution and organogenesis during skin regeneration.
13 citations
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January 2001 in “Pediatric dermatology” This study reports pseudopili annulati in a dark-haired Chinese girl, identifying the unique appearance and structural characteristics of her hair without finding abnormalities in the cuticle and cortex.
10 citations
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January 2013 in “Journal of The European Academy of Dermatology and Venereology” In this study, a square pulse, low-fluence IPL device used at home significantly reduced terminal hair count by 87% six months post-treatment, with evidence of hair miniaturization similar to professional laser treatments.
January 2019 in “Durham e-Theses (Durham University)” This study utilized advanced imaging techniques to quantify hair damage and dye uptake dynamics, revealing that compound penetration in hair is influenced by molecule size and lipophilicity.
13 citations
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December 1983 in “Canadian journal of zoology” This study found that mesenchymal cell processes from the dermal papilla contact epithelial hair matrix cells through gaps in the basal lamina during hair matrix cell differentiation in mouse vibrissa follicles.
19 citations
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February 2013 in “Journal of Investigative Dermatology” Touch domes in human skin are complex sensory structures not directly linked to hair.
43 citations
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November 1988 in “The Journal of Comparative Neurology” This study examined the sensory innervation of hair follicles in the furry skin of rat hindlimbs, finding significant differences among hair types in their innervation patterns and densities.
7 citations
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February 2002 in “Veterinary Dermatology” This study found that intracorneal vacuoles were common in various parakeratotic skin diseases in dogs, but large vacuoles were exclusively observed in congenital follicular parakeratosis.
January 2025 in “Mansoura Medical Journal” In this animal study, researchers observed that both aging and lower androgen levels in male albino rats led to significant structural changes in meibomian glands, including reduced acinar cell size, diminished meibum secretion, and increased collagen deposition.
January 2017 in “Durham e-Theses (Durham University)” This study developed new label-free imaging methods to analyze human hair, identifying distinct chemical environments within cuticle layers and changes in hair structure caused by depilatories, while showing that the treatments tested did not significantly affect skin cell differentiation or proliferation.
36 citations
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January 1994 in “Cell and Tissue Research” 
5 citations
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March 2009 in “Pediatric Dermatology” The study found that pili bifurcati causes hair to intermittently split into two branches, each with its own outer layer.
5 citations
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March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.
3 citations
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November 2021 in “Applied Microscopy” This article presents a comprehensive overview of hair microscopy techniques and their diagnostic potential for systemic and cutaneous disorders, emphasizing its usefulness in resource-limited settings and highlighting the underutilization of this non-invasive method due to lack of awareness.
This review discusses the use of hair microscopy in diagnosing hair-related conditions, highlighting techniques and common applications, but presents no new experimental results.
This review discusses the advancements and applications of multiphoton microscopy in dermatology, including its role in imaging skin disease and drug transport, and reports no new clinical results.
13 citations
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January 2012 in “International journal of trichology” This case study describes a 14-year-old girl with pili annulati who had fragile hair, which may be due to cavities within the hair shafts as seen in electron microscopic examinations.
11 citations
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January 2012 in “Archives of Dermatology” Polarized microscopy is a quick and free method to correctly identify types of hair loss.
June 2026 in “Journal of Cutaneous Pathology” This study found that polarized light microscopy is more effective than diffractive microscopy in distinguishing scarring from non-scarring alopecia, providing a highly specific adjunct diagnostic tool for alopecia biopsy specimens.
This study utilized polarized light microscopy to examine hair shafts in ten children with rare genetic disorders, such as Netherton syndrome and ectodermal dysplasia, providing valuable diagnostic insights into hair thickness, composition, and structural irregularities associated with these conditions.