62 citations
,
July 2018 in “Lasers in Medical Science” In this review, the researchers highlight LED therapy as an emerging and safe treatment for skin inflammatory conditions, aging, and hair growth disorders, noting its integration into dermatological practice but emphasizing the need for more controlled studies to confirm its efficacy.
16 citations
,
November 2016 in “Journal of Cosmetic and Laser Therapy” This review highlights that laser and light treatments could serve as safe and effective alternatives to current therapies for alopecia areata, with the excimer laser showing positive results, though further randomized controlled trials are necessary to establish optimal treatment protocols.
8 citations
,
November 2020 in “Optics and Laser Technology” This review discusses the applications and advantages of LED-based photobiomodulation therapy for dermatological and cosmetic purposes but highlights existing challenges and health concerns while exploring future perspectives.
15 citations
,
October 2017 in “Journal of Cosmetic and Laser Therapy” This review identifies FDA-cleared home-use photobiomodulation devices for androgenetic alopecia treatment and highlights their excellent safety profile but notes the lack of long-term comparative studies.
25 citations
,
October 2012 in “Dermatologic clinics” This article reviews the principles and practical considerations of laser and light-based hair removal techniques, but it does not report new clinical findings.
1057 citations
,
November 2011 in “Annals of Biomedical Engineering” This review discusses the applications of low level laser therapy (LLLT) in wound healing, pain reduction, and treating various conditions, but reports no new clinical results; the authors highlight the need for randomized controlled trials for serious diseases.
33 citations
,
January 2021 in “Aesthetic Surgery Journal” This review suggested that low-level light therapy using red/near-infrared light could be a safe and effective treatment for various skin and hair conditions, though more robust trials are needed to solidify its clinical utility.
19 citations
,
September 2015 in “Therapeutic Delivery” This review discusses the application of active transdermal technologies in cosmetic devices for skin restoration and enhancement, reporting no new clinical results.
73 citations
,
April 1999 in “Dermatologic Clinics” This article reviews patient selection and treatment protocols for various light-based hair removal systems but presents no new clinical results.
65 citations
,
March 2016 in “Lasers in Medical Science” This review found that many low-level light therapy studies report beneficial effects but often fail to provide adequate measurement details, affecting the reliability and repeatability of the research.
19 citations
,
February 2018 in “Lasers in Medical Science” This study found that 655-nm red light with LED enhanced hair shaft elongation and reduced catagen transition in human hair follicles in vitro by activating the Wnt/ß-catenin signaling pathway.
11 citations
,
June 2020 in “Journal of cosmetic dermatology” In this study, a home-use microneedle device combined with 5% minoxidil showed potential for enhancing hair growth in pattern hair loss over six months, although the observed improvements in hair count and patient assessments were not statistically significant compared to other treatments.
4 citations
,
February 2014 in “Proceedings of SPIE” This review discusses the diverse applications of low-level laser therapy in aesthetic dermatology, especially for managing alopecia, but notes that comprehensive literature on its effectiveness is lacking.
August 2025 in “Aesthetic Cosmetology and Medicine” In this article, researchers explored how blue light exposure affects the scalp and hair follicles, highlighting oxidative stress and hair growth disruptions, while emphasizing the importance of protective strategies like antioxidants and limiting light exposure.
January 2003 in “Research Portal (King's College London)” This study employed a laser-based method to analyze how light reflection patterns vary on human hair fibers, revealing changes related to hair color and the tilt of the cuticle cells.
This study suggests that a combination of blue light photobiomodulation and biomimetic peptide infiltrations may effectively increase hair density in patients with androgenetic alopecia.
46 citations
,
September 2010 in “Southern Medical Journal” This review discusses low-level light therapy for androgenetic alopecia and female pattern hair loss, noting minimal clinical evidence on its efficacy and the need for more controlled studies.
6 citations
,
August 1993 in “Archives of Dermatology” This study found that polymorphous light eruption (PLE) may include a wide range of conditions, requiring careful differentiation from similar skin disorders such as benign summer light eruption.
5 citations
,
October 2020 in “Lasers in Medical Science” This study found that combination therapy with LLLT and 5% minoxidil improved hair diameter and density more effectively than each treatment alone in women with female pattern hair loss.
May 2014 in “Journal of Investigative Dermatology” This article reviews recent imaging and genetic tool advances that enable in vivo study of hair regeneration and assessment of skin parameters, but it reports no new clinical results.
June 2011 in “CRC Press eBooks” Low-Level Laser Therapy can stimulate healing and cell function, potentially leading to wider medical use.
April 2021 in “Journal of Investigative Dermatology” This study explored the use of an AI-driven device, HairMetrix, to quantitatively assess the effects of PRP treatments on scalp health in two Caucasian women with androgenetic alopecia, reporting increases in average hair width and follicle count after one treatment.
70 citations
,
April 2017 in “Lasers in surgery and medicine” This study found that blue light at a wavelength of 453 nm promoted hair growth ex vivo, potentially through interacting with OPN3 receptors in human hair follicles.
9 citations
,
August 2017 in “Photochemistry and Photobiology” This study found that isolated red light may serve as an alternative for photo-immunotherapy without additional photosensitizers, as it did not reduce keratinocyte differentiation markers or increase photo-oxidative damage, unlike treatment with IL-4 or UVA1/blue light.
April 2024 in “Frontiers in cellular and infection microbiology” This review highlights evidence supporting the potential of blue light therapy as a non-invasive treatment for managing skin and hair conditions by modulating interactions between the skin microbiome and its host.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that low-dose blue light (453nm) may positively affect hair growth by interacting with the receptors CRY1 and OPN3 in hair follicle cells.
September 2017 in “Journal of Investigative Dermatology” In this study, low-dose 453 nm blue light appeared to enhance hair growth by interacting with specific photoreceptors in the outer root sheath cells.
195 citations
,
January 2008 in “Photochemistry and Photobiology” This review discusses the effects of visible light on human skin, highlighting its role in pigmentation, thermal damage, and the treatment of several skin conditions, while noting limited sunscreen protection against it; no new clinical results are reported.
90 citations
,
January 2009 in “Journal of cosmetic and laser therapy” In this study, low-level laser therapy showed no statistically significant improvements in hair growth measures, despite some patients experiencing increases in terminal hairs and shaft diameter.
23 citations
,
April 1999 in “Dermatologic Clinics” This study found that the Epilight multiple wavelength pulsed-intense light source was effective for long-lasting hair removal, particularly in individuals with dark hair and light skin.