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Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

The IRS-2 Asp/Asp genotype may increase the risk of PCOS in Chinese women, especially if they are not obese.

Mutations in Plcd1 and Plcd3 together cause severe hair loss in mice.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

Androgens may worsen COVID-19 and hair loss could indicate the disease's severity.

Avicennia marina extract and avicequinone C can potentially promote hair growth and treat hair loss by interfering with hair loss mechanisms and boosting growth factors.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Hair loss needs more research for better treatments.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Mutant mice help researchers understand hair growth and related genetic factors.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.