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The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Oxidative stress contributes to hair graying and loss as we age.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Eclipta alba extract may help hair grow similarly to Minoxidil.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

MIM is crucial for hair follicle formation and regeneration by controlling cilia formation and hedgehog signaling through its interaction with Cortactin and Src.

Most women with PCOS have high levels of male hormones, and free testosterone is the best marker for this.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Zinc is crucial for nutrition, especially in patients with specific health conditions, and requires careful supplementation and monitoring.

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.

Lowering testosterone speeds up wound healing in male mice.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.