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PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

A new gene mutation causes insulin resistance in a girl and her mother.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

Genetic testing confirmed a rare skin disorder in a young girl, which improved with zinc supplementation.

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Estrogen therapy can reduce skin aging but has cancer risks.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

A new protein was made to detect specific skin cell growth receptors and worked in normal skin but not in skin cancer cells.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.