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Microneedling combined with platelet-rich plasma therapy is more effective for hair regrowth in androgenic alopecia than microneedling alone, but it's more painful.

Edar signaling is crucial for proper hair follicle development and function.

IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.

Adding a second method to PROTACs could improve cancer treatment.

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Different ligands change the shape of the TRPV3 ion channel in unique ways.

GDNF signaling helps in hair growth and skin healing after a wound.

Two new mutations in the AR gene linked to severe androgen insensitivity were found.

Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

RXRα is crucial for proper immune response and links diet to immune function.

PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.

mEphA1 receptor tyrosine kinase is important for skin and hair development and may play a role in certain diseases.

Notch signalling helps skin cells differentiate and prevents tumors.

Metabolic signals and cell shape influence how cells develop and change.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Hairless protein can block vitamin D activation in skin cells.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Skin side effects from cancer drugs targeting EGFR can affect treatment adherence but can be managed with antibiotics like tetracycline.

Androgen self-administration might be controlled by membrane receptors, not nuclear ones.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.

Notch signaling disruptions can cause various skin diseases.

CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.

PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.

Minoxidil can reduce functions related to androgen receptors.

Vitamin D receptor is important for regulating hair growth and wound healing in mice.

Cattle skin has leptin which might control skin and hair growth.

TLR4 is important in aging-related diseases and could be a new treatment target.

Excessive sun protection might cause frontal fibrosing alopecia by disrupting skin immune balance.