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The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Hair loss from hormone therapy in breast cancer patients can be improved with minoxidil treatment.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.

Endocrine therapies for cancer significantly increase the risk of hair loss.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Finasteride and flutamide effectively reduce hirsutism in PCOS women, with flutamide also lowering hormone levels.

Certain hormone treatments can improve acne and related conditions in women.

Finasteride reduces male rat fertility by causing issues with copulatory plug formation.

Low-dose flutamide helps reduce excessive hair growth and is even more effective with birth control, without bad effects on blood fats.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Finasteride reduces hair growth and is safe for women with excessive hair.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.

Using finasteride with TIP extends time off period for prostate cancer patients.

Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.

Woodhouse-Sakati syndrome often causes sexual development issues, hair loss, learning disabilities, deafness, muscle contractions, limb pain, and diabetes.

Recent genetic insights show that low-renin hypertension includes a range from essential hypertension to secondary or familial forms, affecting diagnosis and treatment.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Antiandrogens are effective for conditions like prostate cancer and skin issues, but more research is needed to confirm their benefits and minimize side effects.

Taking 5α-reductase inhibitors does not significantly increase the risk of breast cancer in men.

PCOS is a complex disorder managed by treating symptoms and requires a team of specialists.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Treatment during development affects hormone balance and sexual behavior in male rats.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.