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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

Spironolactone most effective for hirsutism, but has side effects.

Women with polycystic ovary syndrome tend to have a longer distance between the clitoris and anus.

Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.

Women with polycystic ovary syndrome tend to have a longer anogenital distance.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Obese women had more testosterone and less acne, but similar hair growth compared to non-obese women.

We need better ways to test and understand SARMs to make safer and more effective treatments.

The IRS-2 Asp/Asp genotype may increase the risk of PCOS in Chinese women, especially if they are not obese.

Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.

Higher early lead exposure is linked to delayed puberty in girls.

Ovarian drilling surgery is not clearly better than medical treatments for PCOS symptoms.

Anovulatory PCOS patients are younger with longer cycles and higher blood pressure and hormone levels.

The girl's unexpected pubic hair growth led to a diagnosis different from complete androgen insensitivity syndrome.

Low estrogen compared to androgen may cause female hair loss.

Gene mutations can cause problems in male genital development.

Androgens significantly affect female hair loss, and hormonal treatments may help.

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

Anorexia Nervosa and Bulimia Nervosa are complex eating disorders with increasing incidence among young females, significant morbidity, and varying mortality rates, requiring more research for better treatment.

PSA testing is a reliable method for detecting prostate cancer, and opioids may lower PSA levels, but triglycerides don't affect prostate cancer risk.

Higher urethral PSA levels after prostate removal surgery may be linked to more hair loss and higher PSA levels post-surgery.

Opioid use may lower PSA levels, suggesting a possible role in prostate cancer control; PSA testing is useful for detecting prostate cancer; serum triglycerides are not linked to prostate cancer risk; and higher urethral PSA levels may be associated with local hormone activity.

The document does not confirm if radical prostatectomy is the best treatment for locally advanced prostate cancer.

Serum triglyceride levels are not linked to prostate cancer risk.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

Women with polycystic ovary syndrome have a higher risk of certain fractures.

Both treatments reduced excessive hair growth in PCOS, but there was no difference in weight, hair score, hormone levels, or insulin resistance.