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The exact identity of skin stem cells and how skin cells differentiate is not fully known.

Organoid technology is advancing and entering commercial use, with applications in disease modeling, drug development, and personalized medicine.

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.

Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.

Fibroblast state switching is crucial for skin healing and development.

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

Scientists created a functional 3D skin system from stem cells that can be transplanted into wounds.

Alpinetin helps grow hair by turning on hair stem cells and is safe for use.

Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.

Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.

The research showed how melanocytes develop, move, and respond to UV light, and their stem cells' role in hair color and skin cancer risk.

HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.

A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

Most hair follicle stem cells do not protect their DNA by dividing it unevenly.

Porcine acellular dermal matrix treatment helps wounds heal faster and reduces scarring by affecting Jag1 in skin stem cells.

Different types of stem cells help maintain and heal skin.

Intermediate filaments are crucial for cell differentiation and stem cell function.

Aging changes hair stem cells and their environment, leading to gray hair and hair thinning, but understanding these changes could help develop treatments for hair regeneration.

A small group of slow-growing cells causes basal cell carcinoma to return after treatment.

LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.

LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

LGR5 is a marker found in hair follicle stem cells in various species and is important for hair growth and skin repair.

A synthetic octapeptide may help promote hair growth and counteract hair loss.

The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.

Four specific genes are linked to keloid formation and could be potential treatment targets.

Type 2 diabetes slows down skin and hair renewal by blocking important stem cell activation in mice.