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In vivo lineage labelling is better than in vitro methods for identifying and understanding stem cells.

Stem cell niches support, regulate, and coordinate stem cell functions.

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

The document concludes that stem cell inactivity is actively controlled and important for tissue repair and balance.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Eating fewer calories improves the ability of stem cells to repair and renew the body in various tissues.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

PRC2 is essential for maintaining intestinal cell balance and aiding regeneration after damage.

Low-dose radiation affects hair stem cell function and survival by changing their genetic material's structure.

Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.

Targeting colon cancer stem cells might lead to better treatment results.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

Epithelial stem cells can adapt and help in tissue repair and regeneration.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Stem cell self-renewal is complex and needs more research for full understanding.

Different small areas within hair follicles send specific signals that control what type of cells stem cells become.

CD4+ skin cells may be precursors to basal cell carcinoma.

A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.

Eating less can improve stem cell function and increase lifespan.

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

New techniques have enhanced our understanding of how stem cells function and the role of mutations in aging tissues, which may influence future cancer therapies.