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Flutamide caused damage to male rat reproductive organs and may affect fertility.

Finasteride reduces sperm count and quality and alters hormone levels in mice.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

Nerves are crucial for the regeneration of various body parts in many animals.

Androgens play a key role in hair growth and disorders like baldness and excessive hairiness.

High doses of Lepidium sativum seed extract are toxic and should be used with caution.

Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.

COVID-19 may harm male reproductive health and lower testosterone levels, potentially affecting fertility and causing erectile dysfunction. More research is needed.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

SOX9 is essential for the development of various organs and hair follicles.

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

Obesity and bariatric surgery can cause hair thinning and temporary hair loss due to nutritional deficiencies and stress.

Understanding genes and hormones is crucial for managing male puberty and sex development disorders.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

Testosterone's effects on COVID-19 are unclear and need more research.

Hormones affect prostate health and disease, with certain hormone imbalances linked to prostate cancer and benign prostatic hyperplasia.

Acanthus ebracteatus Vahl. extract and verbascoside may help prevent hair loss and promote hair growth due to their anti-inflammatory properties and ability to protect against cell death.

Dutasteride may help protect neurons and reduce inflammation in Parkinson's disease.

Men with higher androgen levels may have severe COVID-19 symptoms, but those on antiandrogen therapy are less likely to contract the virus and have milder symptoms. Anti-androgen drugs could potentially treat COVID-19, but more research is needed.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Androstanediol glucuronide is a reliable marker for hirsutism in women.

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

Lowering testosterone speeds up wound healing in male mice.

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

A new gene, JMJD1C, may affect testosterone levels in men.

New treatments for male hypogonadism are effective and should be personalized.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.