Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This communication reports previously unreported side effects, severe bullous dermatosis and onycholysis, in three patients undergoing high-dose methotrexate and leucovorin calcium therapy, impacting their chemotherapy schedules.

This article reviews methotrexate's pharmacokinetics and toxicity, emphasizing the role of urinary excretion and leucovorin in avoiding most toxic reactions; it provides no new clinical results.

This case report highlights a rare instance of severe multi-organ involvement following a single dose of methotrexate for ectopic pregnancy, requiring intensive care but ultimately successfully treated with leucovorin and supportive care.

This review discusses insights into the role of lipase H in controlling hair form and texture, emphasizing genetic mutations linked to autosomal recessive woolly hair/hypotrichosis, and reports no new experimental results.

A cancer patient died from a severe skin reaction after taking the drug cetuximab.

This article reviews eyelash elongation as a side effect of EGFR inhibitors in cancer treatment, finding that the condition is typically not severe and may be managed by trimming.

In this case study, researchers reported on a 54-year-old woman who developed methotrexate toxicity after mistakenly taking high doses over five days, which led to mucocutaneous lesions and pancytopenia, highlighting the importance of early recognition and treatment of such toxicities.

This study found that for metastatic colorectal cancer patients, substituting calcium folinate with disodium folinate in combination with fluorouracil and oxaliplatin showed similar effectiveness and safety as the mFOLFOX6 regimen.

This review explores various theories of colorectal cancer stem cell biology and highlights the need for better identification and targeting of these cells to advance treatment strategies, but reports no new clinical findings.

This review elaborates on the skin side effects of chemotherapy and emphasizes identifying and managing both common and life-threatening skin reactions, without presenting new clinical findings.

This article discusses the cutaneous side effects of various chemotherapeutic agents but reports no new clinical results; the authors emphasize the importance of dermatologists recognizing drug-induced skin reactions to better patient care.

This study reported that palliative chemotherapy prolonged overall and quality-adjusted survival in patients with advanced gastric cancer, with improved quality of life compared to best supportive care, but increased costs.

This review discusses advances in protecting against chemotherapy-induced alopecia and reports no new clinical results; calcitriol and cyclosporine A emerged as promising agents in animal models with broader efficacy across multiple chemotherapy drugs.

This study found that the combination of docetaxel, cisplatin, and 5-fluorouracil is active and feasible for treating squamous cell carcinoma of the head and neck, with dose level I recommended for further testing.

This review discusses methotrexate's use in dermatology and its mechanisms, pharmacokinetics, dosing, side effects, interactions, and emphasizes the need for further research into optimizing therapy and predicting adverse events.

This review discusses the causes, clinical presentation, and management of anagen effluvium, emphasizing its psychological impact and the need for empathy and practical support, but reports no new results.

This article reviews therapy-related hair disorders in oncology patients, detailing underlying mechanisms and potential management strategies, but reports no new clinical findings.

This review discusses interventions for chemotherapy-induced hair loss and reports no new clinical results; scalp cooling and nutritional support are considered potential strategies but not yet substantiated.

This study introduces MicrobeFDT, a tool that clusters chemically similar compounds and links them to gut microbial enzymes and toxicities, demonstrating its utility by uncovering previously unknown metabolism of the cancer drug altretamine.

In patients undergoing treatment with capecitabine for colon cancer and metastatic breast cancer, this study observed that hand-foot syndrome occurred more frequently than with intravenous 5-FU, but other side effects were less common.

This review discusses medication-induced gray hair repigmentation, highlighting that certain anti-inflammatory drugs and melanogenesis stimulators can cause diffuse repigmentation, though evidence remains low-quality and these medications are not currently indicated for this purpose.

This study reviewed the current state of intralesional therapy for keratoacanthoma, finding that while methotrexate, 5-fluorouracil, and interferon alpha are common agents, guidelines are still needed, and histopathological confirmation is advised to prevent misdiagnosis with squamous cell carcinoma.

This study identified 14 genes affected by copy number variants that may contribute to alopecia areata, including four genes notably involved in autophagy and chromatin remodeling.

This study found that inhibiting EGFR signaling in mice can prevent alopecia caused by cyclophosphamide treatment, highlighting its potential role in managing chemotherapy-induced hair loss.

This review discusses the cutaneous side effects of chemotherapy, noting that they frequently involve changes to skin, hair, and nails, and reports no new results.

This review discusses the current medical treatments for hepatocellular carcinoma, noting that while new local therapies show high response rates, their true impact on patient survival is uncertain.

This review examines the interaction between hedgehog and Wnt/β-catenin signalling in hair follicles and basal cell carcinoma, linking Hh pathway inhibition to both tumor regression and alopecia.

This article reviews assessment and management strategies for adolescent females with excessive hair growth and highlights the importance of evaluating potential androgen sources.

This review examines the role of topoisomerase-interacting drugs in cancer treatment and emphasizes the importance of understanding their mechanisms for clinical development, but it presents no new results.

Targeted therapies for lung cancer are effective but require careful management of side effects to benefit patients.