30 citations
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April 2007 in “Journal of Leukocyte Biology” This study found that anti-CD44 treatment inhibited leukocyte migration in alopecia areata and eczema, suggesting targeted therapies could enhance contact sensitizer treatment for alopecia areata.
May 2022 in “Journal of Immunology” In this study, a TGF-β mimic molecule from Heligmosomoides polygyrus was observed to enhance wound healing in mice, with improved tissue regeneration and specific immune cell recruitment without increased scarring.
March 2026 in “Frontiers in Immunology” This review highlights the complex role of leukocyte migration in both driving inflammation and facilitating its resolution, suggesting that targeted modulation of this process could improve therapeutic strategies for inflammatory diseases.
24 citations
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May 2006 in “Journal of Investigative Dermatology” This study found that allergen treatment in alopecia areata mice appeared to alter leukocyte subset distribution and impaired dendritic cell migration, which may affect T-cell activation and hair follicle recovery.
July 2025 in “Annals of Human Genetics” This review examines the genetics of acne vulgaris, concluding that stem/progenitor cell maintenance and cellular migration are key processes in its pathogenesis, potentially shifting future treatment strategies beyond traditional antibiotics and retinoids, which have notable side effects.
March 2017 in “Open access journal of surgery” This review discusses the historical development of platelet-rich fibrin from fibrin glue to platelet-enriched formulations and reports no new clinical results.
77 citations
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June 2002 in “Journal of Investigative Dermatology” CD44 variant changes start alopecia areata, but don't maintain it.
6 citations
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January 2021 in “Annals of Dermatology” This study found that 650-nm red light treatment promoted hair follicle proliferation and delayed the transition from anagen to catagen in ex vivo hair follicles from androgenetic alopecia patients, with RNA-seq analysis suggesting involvement of biological processes like metabolism and leukocyte migration.
October 1982 in “American Journal of Nursing” Wound healing is a complex process involving different cells and stages, leading to scar tissue formation and strength increase over time.
28 citations
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September 2020 in “International Journal of Molecular Sciences” This study concluded that leucocyte-rich PRP has a continuous stimulatory effect on human fibroblast cells, enhancing their proliferation, migration, and impacting gene expression of the extracellular matrix and adhesion molecules.
November 2023 in “Periodontology 2000” This narrative review examines the technological advancements and clinical applications of liquid injectable platelet-rich fibrin (i-PRF), discussing its use across regenerative periodontology, sports medicine, and more, as well as its potential as a drug delivery system.
33 citations
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October 2006 in “European Journal of Immunology” This study found that CD44 and CD49d together enhance signaling pathways in lymphocytes in mice with alopecia areata, influencing their activation and function.
16 citations
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July 2018 in “Dermatologic Surgery” In this study, iL-PRF injections produced significantly better clinical scores for androgenetic alopecia patients compared to controls, especially in those with more severe baseline conditions.
2 citations
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July 1982 in “British Journal of Dermatology” This study reports that retinol acetate inhibited the pro-oxidant effects of benoxaprofen on polymorphonuclear leucocytes in vitro.
19 citations
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May 2020 in “Cells” This study found that 5% primed conditioned medium from human umbilical cord blood-derived mesenchymal stromal cells significantly improved hair density, thickness, and growth rate in patients with androgenetic alopecia.
6 citations
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April 2025 in “Communications Biology” In this study, researchers used a murine model of irritant contact dermatitis to reveal that hair follicle regions serve as key sites for neutrophil transepidermal migration, which requires MMP-9 expression stimulated by dermal monocytes.
37 citations
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November 2003 in “Veterinary pathology” This study showed that in C3H/HeJ mice, focal follicular inflammation starts before overt hair loss, with inflammation severity possibly reaching a threshold causing hair follicle dystrophy prior to visible hair loss.
64 citations
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July 2016 in “Journal of Immunology” In this study, blocking the CXCR3 receptor in mice prevented the development of alopecia areata by inhibiting the accumulation of specific T cells in the skin, suggesting a potential therapeutic approach for humans.
April 2026 in “Microsystems & Nanoengineering” This study developed HA-gel-dex hydrogels with enhanced ECM-like properties and functionality, showing promise for 3D bioprinting, tissue repair, and as wound dressings due to improved cell interaction, cytocompatibility, antimicrobial synergy, and wound healing in mice compared to traditional ECM bio-inks.
54 citations
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July 2017 in “Scientific Reports” This study found that the JMJD3/NF-κB-Notch1 pathway plays a crucial role in regulating keratinocyte migration and skin wound healing, with Notch1 affecting key genes involved in cell migration.
July 2025 in “Journal of Research in Pharmacy” This study found that using a combination of Virgin Coconut Oil and Nigella Sativa Oil improved wound healing in diabetic rats by reducing inflammation and enhancing skin thickness compared to single treatments or controls, suggesting a potentially valuable approach for managing diabetes-related wounds.
3 citations
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July 2022 in “Stem Cell Research & Therapy” This study found that knocking out the integrin β1 subunit in induced pluripotent stem cells enhanced their migration and improved their wound-healing effects in a mouse model.
87 citations
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September 2014 in “International Journal of Molecular Sciences” This study found that the transcription factor FOXO1 plays a crucial role in wound healing by protecting keratinocytes from oxidative stress and regulating TGF-β expression.
28 citations
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January 2016 in “Vitamins and hormones” This source reports that thymosin beta 4 accelerated dermal wound repair in phase 2 clinical trials for pressure ulcers, stasis ulcers, and epidermolysis bullosa wounds and was well tolerated.
29 citations
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November 2014 in “Experimental Dermatology” This study found that α-MSH administration before skin wounding in adult mice reduced inflammation and scar area, suggesting a potential pathway to more regenerative healing.
13 citations
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January 2020 in “Scientific Reports” This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.
65 citations
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June 2020 in “Stem Cell Research & Therapy” This review discusses recent advances in how proinflammatory cytokines affect epidermal stem cell function during skin wound healing and introduces potential therapies targeting these cells and cytokines.
64 citations
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August 2014 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study found that biallelic mutations in the TTC7A gene affect lymphocyte and gut epithelial cell function, thereby contributing to the development of inflammatory bowel disease in patients.
54 citations
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December 2014 in “Wound Repair and Regeneration” This study observed that autologous PRP and PDRN injections improved hair thickness and density in women with pattern hair loss, with combined therapy showing greater improvement in thickness than PDRN alone.
42 citations
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February 2018 in “International Journal of Molecular Sciences” This study suggests that minoxidil may enhance hair growth by stimulating adipose-derived stem cell motility and growth factor secretion, promoting dermal papilla cell proliferation and accelerating anagen induction.