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Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production

research Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production

17 citations, August 2007 in “Bioorganic & Medicinal Chemistry Letters”

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

research N-Acyl Arylsulfonamides as Novel, Reversible Inhibitors of Human Steroid Sulfatase

17 citations, December 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists found new, better-working inhibitors for a hormone-related enzyme.

research Preparation and Characterization of Solution-Processed Nanocrystalline p-Type CuAlO2 Thin-Film Transistors

14 citations, August 2018 in “Nanoscale Research Letters”

Turmeric may improve knee osteoarthritis, depression, and metabolic syndrome, but evidence is weak.

(1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production

research (1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production

14 citations, August 2007 in “Bioorganic & Medicinal Chemistry Letters”

The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.

Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

14 citations, February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research Simultaneous Determination of Seven Prohibited Substances in Cosmetic Products by Liquid Chromatography–Tandem Mass Spectrometry

13 citations, April 2013 in “Chinese Chemical Letters/Chinese chemical letters”

The method effectively identifies and measures seven banned substances in cosmetics.

research 3,3-Diphenylpentane Skeleton as a Steroid Skeleton Substitute: Novel Inhibitors of Human 5α-Reductase 1

13 citations, August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

4-(Alkylthio)- and 4-(Arylthio)-Benzonitrile Derivatives as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

research 4-(Alkylthio)- and 4-(Arylthio)-Benzonitrile Derivatives as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

11 citations, March 2009 in “Bioorganic & Medicinal Chemistry Letters”

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

11 citations, August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

research Polycystic Ovary Syndrome and Acne

10 citations, November 2010 in “Skin therapy letter”

Women with PCOS often have acne because of high androgen levels, and the article reviewed how to treat this type of acne.

Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration

research Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration

9 citations, September 2017 in “Nanoscale Research Letters”

Graphene oxide helps deliver a skin healing agent over time, improving skin and hair follicle regeneration.

research Synthesis and Activity of 8-Substituted Benzo[c]quinolizin-3-ones as Dual Inhibitors of Human 5α-Reductases 1 and 2

9 citations, November 2004 in “Bioorganic & Medicinal Chemistry Letters”

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

research Smoothened Antagonists for Hair Inhibition

7 citations, June 2010 in “Bioorganic & medicinal chemistry letters”

Two new compounds were found to effectively reduce hair growth in mice.

research Diphenyl Ethers as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

7 citations, April 2009 in “Bioorganic & Medicinal Chemistry Letters”

Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.

research Synthesis of Minoxidil Conjugates and Their Evaluation as HL-60 Differentiation Agents

6 citations, January 2016 in “Bioorganic & Medicinal Chemistry Letters”

Some minoxidil combinations can help differentiate leukemia cells without harming other cells.

Synthesis and Structure–Activity Investigation of Iodinated Arylhydantoins and Arylthiohydantoins for Development as Androgen Receptor Radioligands

research Synthesis and Structure–Activity Investigation of Iodinated Arylhydantoins and Arylthiohydantoins for Development as Androgen Receptor Radioligands

6 citations, November 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.