June 2022 in “Scientific Reports” This study found that prevelex coatings on microwell array devices enhanced the formation of uniform cell spheroids and enabled the development of hair follicles in tissue engineering applications.
27 citations
,
September 2015 in “PharmaNutrition” This article discusses various potential health benefits and increasing global interest in astaxanthin but presents no new clinical results, though ongoing trials are exploring its effects on chronic diseases and other conditions.
13 citations
,
November 2015 in “Gene” In this study, TGFβR I was more highly expressed in alpaca ear skin than in back skin, suggesting it may inhibit coat hair growth, with let-7b downregulating TGFβR I protein through transcriptional repression.
3 citations
,
February 2020 in “The Egyptian Rheumatologist” This case report from Tishreen Hospital describes the rare presentation of lupus erythematosus tumidus and autoimmune thyroid dysfunction as initial manifestations of systemic lupus erythematosus, highlighting the importance of early diagnosis for better outcomes.
June 2026 in “Journal of Nanobiotechnology” This study reported that human umbilical cord mesenchymal stem cell-derived exosomes may promote hair regeneration and thickness in androgenic alopecia by modulating cellular pathways in hair growth, including increasing hair density and diameter, as observed in a mouse model and an exploratory clinical trial.
July 2023 in “Nature Reviews Chemistry” A new method strengthens hair without using harmful chemicals.
November 2024 in “Genomics” This study found that exogenous melatonin enhances the development of secondary hair follicles in Cashmere goats by promoting miRNA-mRNA interactions, specifically via the chi-let-7d-5p/WNT2 axis, which suggests a mechanism for melatonin's effects on hair growth involving microRNA regulation.
3 citations
,
October 2011 in “QJM” This study found that 5α-reductase inhibitors significantly reduced low-grade prostate cancer incidence in men but nearly doubled the incidence of high-grade prostate cancers.
10 citations
,
January 2023 in “Molecular and Cellular Biochemistry” This review discusses the potential therapeutic role of the edible plant Solanum nigrum for managing COVID-19 symptoms and post-COVID complications based on in silico docking and pharmacological studies, but reports no new clinical results.
October 2025 in “Frontiers in Pharmacology” This review explores the immunopharmacological potential of A. lappa for inflammatory musculoskeletal disorders (IMSDs) but reports no new clinical results, emphasizing the need for standardized research methodologies.
1066 citations
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March 2010 in “Nature Reviews Molecular Cell Biology” This review discusses the potential regulation of signal transduction pathways by microRNAs in animal cells, aiming to identify biological processes that may be influenced by miRNA-mediated regulation, but it reports no new experimental outcomes.
150 citations
,
December 2012 in “EMBO Reports” This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.
74 citations
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June 2021 in “Frontiers in Cell and Developmental Biology” This study suggests that exosomal miRNAs from human amniotic fluid stem cells may inhibit myofibroblast differentiation and reduce fibrotic scarring in wound healing.
32 citations
,
February 2019 in “Journal of neurochemistry” This study found that pharmacological inhibition of sex steroid synthesis impacts pathogenic processes in traumatic brain injury in a sex-specific manner, with distinct effects of letrozole and finasteride on molecular and neurological outcomes.
28 citations
,
November 2018 in “Journal of cellular physiology” This study found that miR-124 may facilitate the differentiation of hair follicle stem cells into neuronal cells by targeting Sox9 and Ptbp1.
19 citations
,
September 2010 in “Journal of the European Academy of Dermatology and Venereology” This study found that while the CLASI is generally useful for assessing disease activity and damage in cutaneous lupus erythematosus, it may not accurately reflect all subtypes, indicating a need for revision.
September 2026 in “Clinical Cosmetic and Investigational Dermatology” This case report highlights the diagnostic challenges in a patient with atypical lupus erythematosus tumidus due to long-term misdiagnosis and conflicting pathological findings, with effective treatment achieved using hydroxychloroquine and methylprednisolone.
March 2021 in “Annals of Translational Medicine” This report presents two cases of systemic lupus in male patients with a distinct form of alopecia that combines both scarring and non-scarring elements, highlighting the variability in lupus-related hair loss presentations.
December 2025 in “Preprints.org” This study investigated bovine milk-derived exosomes and found they significantly increased dermal papilla cell viability and up-regulated WNT pathway components in human hair follicles, suggesting potential therapeutic value for hair loss disorders like androgenetic alopecia and telogen effluvium.
August 2025 in “Stem Cell Research & Therapy” This study found that exosomes from human umbilical cord mesenchymal stem cells significantly promoted hair follicle growth and enhanced the transition to the growth phase in a model of androgenetic alopecia, by enriching specific microRNAs that activate key pathways involved in hair regeneration.
33 citations
,
December 2017 in “Saudi Journal of Biological Sciences” In this study, researchers found that microRNAs in the oar-let-7 and oar-miR-200 families were significantly up-regulated during critical fetal periods of cashmere goat hair follicle development, suggesting their role in this process.
8 citations
,
July 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified four circulating microRNAs as highly predictive of frontal fibrosing alopecia status, suggesting potential roles in diagnostics and disease understanding.
September 2017 in “Journal of Investigative Dermatology” This study found that certain circulating miRNAs in skin and plasma may serve as potential biomarkers for distinguishing frontal fibrosing alopecia from control cases, highlighting the need for further validation in larger cohorts.
13 citations
,
November 2022 in “Future Journal of Pharmaceutical Sciences” This review examines liposome-based cosmeceuticals for various skin conditions and reports no new clinical results, highlighting the potential promise these formulations offer for future applications.
1 citations
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August 2000 in “Expert Opinion on Therapeutic Patents” This article reviews the therapeutic use of carnitine derivatives for re-establishing mitochondrial functionality in aging and reports no new clinical results.
4 citations
,
February 2019 in “Breast Cancer Research and Treatment” This study found that applying a 1% sodium N-(dihydrolipoyl)-l-histidinate zinc complex lotion to the scalp did not prevent chemotherapy-induced alopecia in breast cancer patients, but it may aid recovery.
July 2022 in “L Endocrinologo” This case report describes a 77-year-old woman with female pattern hair loss and elevated testosterone levels, who showed no improvement with minoxidil and lacked adrenal tumors on imaging.
9 citations
,
July 2013 in “Experimental Dermatology” This study demonstrates that the ability of human hair follicle keratinocytes to form clones decreases with ageing.
192 citations
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March 1998 in “British Journal of Dermatology” This study found that minoxidil significantly increases VEGF mRNA and protein expression in dermal papilla cells, suggesting a role in enhancing hair follicle vascularization in androgenetic alopecia.
27 citations
,
February 2009 in “Autoimmunity Reviews” This study describes the development of the EUSCLE Core Set Questionnaire for cutaneous lupus erythematosus, designed to standardize data collection, facilitate epidemiological analysis, and guide diagnostic and therapeutic strategies across European centers.