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JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.

The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

Insulin-lowering medications show promise for PCOS symptoms but can't be the main treatment yet due to limited long-term research.

The document concludes that understanding hair follicle cell cycles is crucial for hair growth and alopecia research, and recommends specific techniques and future research directions.

Weight loss and metformin don't significantly change vaspin levels in women with PCOS.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

The document concludes that treating PCOS requires a combination of drugs to manage reproductive and metabolic symptoms, with more research needed on combination therapies.

Sweat glands and hair follicles are structurally connected within a specific layer of skin fat.

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

A male with aromatase deficiency improved bone health with estradiol treatment.

Food deprivation increases MST enzyme in the brain, possibly affecting energy balance.

Cell-based therapies using dermal papilla cells and adipocyte lineage cells show potential for hair regeneration.

Women with PCOS have a higher risk of diabetes, heart problems, certain cancers, and mental health issues, but early treatment can help manage these risks.

Behçet's Disease may be caused by genetic and environmental factors leading to abnormal immune responses, and stress management and new treatments could improve patient outcomes.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Applying calreticulin can speed up wound healing in diabetics.

Some Middle Eastern plants may help treat diabetes and could be alternatives to current drugs, but more research is needed.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.

The conclusion is that future hair loss treatments should target the root causes of hair thinning, not just promote hair growth.

Diagnosing PCOS in teenagers is hard because its symptoms often look like normal puberty, and there's a need for better diagnosis methods and agreement on criteria.

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

People with Lichen Planus, especially with mucosal involvement, are more likely to have Metabolic Syndrome, which increases their risk for heart disease and diabetes.

Girls with PCOS during adolescence have a higher risk of developing type 2 diabetes, and early treatment can help manage this risk.

Mice with CBS deficiency are healthier on a low-methionine diet.

Obesity worsens Polycystic Ovary Syndrome symptoms, and weight loss is a key treatment.