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Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Multiple treatments work best for hair loss.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Skin fat plays a key role in immune defense and healing beyond just storing energy.

Women with regular menstrual cycles and PCOS have linked kisspeptin and LH hormone patterns, unlike those with irregular cycles.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.

Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

A male with aromatase deficiency improved bone health with estradiol treatment.

Cell-based therapies using dermal papilla cells and adipocyte lineage cells show potential for hair regeneration.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.

Adults with certain skin conditions may have higher levels of inflammation in their body.

Certain skin conditions can indicate insulin resistance and should prompt lifestyle changes and medical treatment to manage underlying health issues.

Common Black hair care products may affect hormone levels and potentially impact health, especially in reproductive and metabolic areas.

Both human and animal-derived small extracellular vesicles speed up skin healing equally well.

Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.

Certain genetic markers linked to reproductive potential were identified by their impact on a protein's ability to bind to genes.

Vitamin D deficiency is common in women with PCOS and linked to some metabolic problems, but not the main cause of their metabolic issues.

Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

Early treatment and lifestyle changes are important for managing PCOS in young people to prevent long-term health issues.