10 citations,
August 2022 in “International Journal of Molecular Sciences” Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.
8 citations,
April 2017 in “Experimental Dermatology” More plasma leptin means higher baldness risk in men.
4 citations,
November 2018 in “Journal of comparative pathology” The three adipokines—leptin, adiponectin, and resistin—are present in various cells of normal dog skin.
4 citations,
January 2007 in “Gynecological endocrinology” Low leptin levels in obese women with high testosterone may indicate a tumor that secretes male hormones.
1 citations,
May 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)” Women with idiopathic hirsutism and PCOS have higher RBP4 levels, and PCOS is linked to greater insulin resistance; weight management may help both conditions.
MFN2 mutations cause mitochondrial problems, leading to more upper body fat and lower leptin levels.
November 2023 in “British journal of nutrition” Curcumin supplements increase adiponectin and decrease leptin in adults.
MFN2 mutations cause mitochondrial problems, unusual fat distribution, and low leptin despite high body fat.
December 2020 in “Journal of Endocrinology and Reproduction” Certain inflammatory molecules and leptin may contribute to hair loss in cicatricial alopecia.
April 2017 in “Journal of Investigative Dermatology” Higher leptin levels link to hair loss.
5 citations,
August 2015 in “Bioscience, Biotechnology, and Biochemistry” Obese mice with a leptin gene mutation have a longer resting phase in their hair cycle, which may help understand certain hair loss conditions.
3 citations,
December 2017 in “Clinical and Experimental Dermatology” Reversible hair loss in a ring pattern on the scalp may be linked to changes in leptin levels in fat tissue.
June 2024 in “Research Square (Research Square)” Young women in West Bengal, India, with PCOS often have estrogen resistance, leptin receptor issues, folate deficiency, T2DM, and acanthosis, commonly linked to obesity.
April 2018 in “Journal of Investigative Dermatology” Researchers found that the Leptin receptor is a consistent marker for hair follicle dermal cells, which may help future hair research.
363 citations,
May 2006 in “Current Opinion in Psychiatry” Anorexia and bulimia lead to serious health problems and increased risk of death, requiring aggressive treatment.
218 citations,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.
155 citations,
March 2006 in “The American Journal of Medicine” Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.
105 citations,
February 2011 in “The Journal of Clinical Endocrinology & Metabolism” Treating sleep apnea in young obese women with PCOS can improve heart health and insulin sensitivity.
69 citations,
November 2010 in “Middle East Fertility Society Journal” PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.
31 citations,
November 2020 in “International journal of molecular sciences” Adipokines affect skin health and could be targeted for treating skin diseases.
30 citations,
January 2013 in “Obesity Surgery” Bariatric surgery affects skin health, causing both direct complications and changes in existing skin conditions, often related to nutritional deficiencies.
23 citations,
September 2011 in “Journal of Dermatological Science” Red LED light helps mouse hair grow by increasing growth factors from skin cells.
20 citations,
July 2013 in “International Journal of Dermatology” Obesity increases the risk of skin infections, inflammatory conditions, and melanoma, but not basal cell carcinoma.
14 citations,
October 2020 in “Journal of ethnopharmacology” Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.
4 citations,
February 2022 in “Nutrients” Korean Red Ginseng saponins may protect skin from inflammation and darkening caused by air pollution.
3 citations,
May 2023 in “Biomedicines” PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.
December 2023 in “Palestinian medical and pharmaceutical journal/Palestinian medical & pharmaceutical journal” Increasing sleep by 41 minutes daily for a month showed no significant changes in metabolism or hormone levels in healthy women.
June 2023 in “British journal of dermatology/British journal of dermatology, Supplement” Two sisters with lipoedematous scalp suggest a genetic influence in the condition.
September 2017 in “Asian Journal of Beauty and Cosmetology” The Notch signaling pathway is important for hair follicle development and could help create treatments for hair disorders.
12 citations,
February 2016 in “Biochemical and Biophysical Research Communications” Sulforaphane may help with hair growth by breaking down a hormone that causes hair loss.