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    Glossary Leflunomide

    medication that treats rheumatoid arthritis by inhibiting immune cell proliferation

    Leflunomide is a medication primarily used to treat rheumatoid arthritis by reducing inflammation and slowing down the immune system's attack on the joints. It works by inhibiting an enzyme called dihydroorotate dehydrogenase, which is crucial for the synthesis of pyrimidine, a building block of DNA and RNA, thereby limiting the proliferation of rapidly dividing cells, such as those involved in the immune response.

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    Research 30 of 113

    1. Leflunomide for the treatment of trichodysplasia spinulosa in a liver transplant recipient Transplant Infectious Disease · 2017 · 22 citations
    2. Alopecia universalis during treatment with leflunomide and adalimumab - Case report 2014 · 16 citations
    3. Recalcitrant alopecia areata responsive to leflunomide and anthralin—Potentially undiscovered JAK/STAT inhibitors? Pediatric dermatology · 2018 · 11 citations
    4. Alopecia areata secondary to the use of leflunomide in patients with rheumatoid arthritis: a case report and literature review Medwave · 2015 · 6 citations
    5. Late onset leflunomide-induced cutaneous ulcers in a seronegative arthritis patient: A case report SAGE Open Medical Case Reports · 2023 · 2 citations
    6. Leflunomide: an unlikely trigger and mechanistically a beneficial drug for alopecia areata Clinical Rheumatology · 2019 · 1 citations
    7. Leflunomide Practical diabetes · 2018
    8. An observational study of leflunomide in the treatment of lupus nephyritis for cyclophosphamide was invalid or could not be tolerated Chinese Medical Journal of Metallurgical Industry · 2010
    9. Leflunomide-Induced Cutaneous Ulcers: A Rare Diagnostic Conundrum Indian Dermatology Online Journal · 2026
    10. Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis Reumatología Clínica · 2017 · 37 citations
    11. Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis Reumatología Clínica (English Edition) · 2019 · 1 citations
    12. Topical delivery of nanoemulsions for skin cancer treatment Applied Materials Today · 2023 · 34 citations
    13. Drug reaction with eosinophilia and systemic symptoms and severe involvement of digestive tract: description of two cases British Journal of Dermatology · 2011 · 19 citations
    14. Viremia and viruria of trichodysplasia spinulosa‐associated polyomavirus before the development of clinical disease in a kidney transplant recipient Transplant infectious disease · 2019 · 10 citations
    15. 08.33 Treatment of rheumatoid arthritis patients: comparative efficacy of four treatment regimens 2017 · 3 citations
    16. Side effects of methotrexate therapy in patients with rheumatoid arthritis Immunopathologia Persa · 2021 · 2 citations
    17. Progressive alopecia areata during TNF-α inhibition with intralesional corticosteroid failure and subsequent improvement following JAK1 inhibition Journal of Dermatological Treatment · 2026 · 1 citations
    18. AB0597 Comparative analysis of safety data of four treatment regimens in early rheumatoid arthritis patients Annals of the Rheumatic Diseases · 2013 · 1 citations
    19. Effect of Systemic Immunomodulators on Incidence of Alopecia Areata: A Retrospective Cohort Study JEADV Clinical Practice · 2025
    20. 0282 Effect of systemic immunomodulators on incidence of alopecia areata: A retrospective cohort study Journal of Investigative Dermatology · 2025
    21. Polyomavirus Associated Trichodysplasia Spinulosa in a Pediatric Kidney Transplant Recipient Pediatric Transplantation · 2025
    22. P13 DMARD preconception counselling and reinforcement should be a norm in all rheumatology clinics Rheumatology Advances in Practice · 2024
    23. THU0189 Safety of four treatment regimens in early rheumatoid arthritis Poster presentations · 2017
    24. A10.09 Safety data of four treatment regimens in early rheumatoid arthritis patients Annals of the Rheumatic Diseases · 2016
    25. New treatments for rheumatoid arthritis Postgraduate Medicine · 1999 · 13 citations
    26. Chemical Synthetic Disease Modifying Drugs (csDMARD) Used forRheumatoid Arthritis Journal of Pakistan Society of Internal Medicine. · 2023
    27. Teriflunomide (Aubagio®) for the treatment of multiple sclerosis Experimental Neurology · 2014 · 36 citations
    28. “Nail loss after teriflunomide treatment: A new potential adverse event” Multiple Sclerosis and Related Disorders · 2017 · 6 citations
    29. Therapeutic Approach to Vaccine-Induced Ischemic Dermatopathy in a Pomeranian Dog with Refractory Alopecia Journal of Veterinary Clinics · 2025
    30. Salivary Gland Inflammation During Acitretin Therapy for Generalized Pustular Psoriasis: a Case Report and Diagnostic Challenge Dermatology Review · 2025