Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study evaluated nanovesicles derived from Polygonum multiflorum roots, finding that they promote dermal papilla cell proliferation and activate β-catenin signaling, which in turn enhances hair shaft elongation in ex vivo cultured human hair follicles, suggesting their potential use for alopecia treatment.

This study found that androgen inactivation pathways in scalp sebaceous glands change with age, specifically noting that AKR1C expression, including AKR1C4 previously thought liver-specific, declines with age and is sex dependent, which could impact hair follicle health during aging.

This study found that a novel nano-engineered platform, PCA, significantly promoted hair regeneration in an androgenetic alopecia mouse model by enhancing angiogenesis and hair follicle stem cell proliferation, showing promise for future hair regrowth treatments.

In this study, PDLLA treatment in middle-aged mice was observed to enhance hair growth by increasing macrophage M2 polarization and hair follicle stem cell proliferation, potentially rejuvenating the skin's microenvironment and offering a novel approach for age-related hair loss.

Certain immune cells in atopic dermatitis skin could be targeted for treatment.

This study found that exosomes from human umbilical cord mesenchymal stem cells significantly promoted hair follicle growth and enhanced the transition to the growth phase in a model of androgenetic alopecia, by enriching specific microRNAs that activate key pathways involved in hair regeneration.

In this animal study, researchers found that local administration of mesenchymal stem cell therapy improved hair regrowth and reduced local inflammatory cytokines in mice with Alopecia Areata, although systemic cytokine levels were unchanged.

This study investigates the potential of umbilical cord mesenchymal stem cells exosome (UCMSC-Exos) to promote hair growth, focusing on its mechanisms of action, though specific results are not reported.

This study found that dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by enhancing fibroblast activity and activating the Wnt/β-catenin signaling pathway in mice.

In this study involving mice on a high-fat diet, piperine from black pepper was observed to reduce sebaceous gland size and fat accumulation, suggesting its potential in controlling hair oiliness by inhibiting adipogenesis in hair stem cells.

This commentary highlights that the loss of the Y chromosome may disrupt UTY/TLE1-RUNX1 interactions, potentially impacting male hematopoietic cell development and leading to conditions like acute myeloid leukemia and T-cell acute lymphoblast leukemia.

This study reported that fire needle therapy improved skin lesions, increased melanocyte numbers, and boosted melanin levels in a vitiligo mouse model by upregulating the Wnt/β-catenin signalling pathway, suggesting its potential role in treating vitiligo through promoting pigmentation.

This study explored hair follicle research by co-culturing dermal papilla cells, keratinocytes, and endothelial cells in spheroids, finding elevated hair growth factor expression and potential for creating skin equivalents with hair through a "hair-on-a-chip" approach.

This study found that an octapeptide binding to Lgr5 can enhance the proliferation and differentiation of human primary hair cells by activating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss in androgenetic alopecia.

This study describes a novel method using force-triggered density gradient sedimentation for efficiently isolating dermal papilla cells from neonatal mouse skin, showing promise for hair follicle regeneration research.

This study suggests that finasteride might reduce SARS-COV-2 infectivity by inducing epigenetic changes in the TMPRss2 protein, which is crucial for viral activation and multiplication.

This study found that DPP4 inhibition in mice can enhance hair follicle activation and regeneration, suggesting a potential therapeutic strategy for improving hair growth and wound-induced hair follicle neogenesis.

The researchers in this study found that neonatal mouse skin fibroblasts show distinct chromatin landscapes directing differentiation into dermal papilla or adipocyte lineages, and such plasticity may inform strategies for enhancing regenerative capacities in adult skin.

In this study, neonatal mouse mesenchymal cells showed hair-inducing capabilities, which were lost during in vitro propagation but could be partially restored through specific high-density culture methods.

This study found that the lignan compound VB-1 may promote hair follicle growth by enhancing Wnt/β-catenin signaling and increasing dermal papilla cell proliferation in vitro.

This study found that VB-1, a vitexin compound, may promote human hair follicle growth by enhancing Wnt/β-catenin signaling in dermal papilla cells.

In this study, VB-1 was reported to promote human hair follicle growth by enhancing Wnt/β-catenin signaling and increasing human dermal papilla cell proliferation in vitro.

This study found that type XVII collagen (COL17) regulates interfollicular epidermis proliferation in both neonatal and aged mice through Wnt signaling, suggesting its potential as a target for anti-aging skin strategies.

This study found that type XVII collagen is crucial for regulating epidermal cells' proliferation in mice and may be a promising target for anti-aging skin treatments.

The study observed that the tumor suppressor activity of bone morphogenetic proteins in mouse skin epithelium depends on Noggin levels, inhibiting Wnt and Shh signaling pathways to prevent tumor initiation and progression.

This review discusses the development of hair-on-a-chip technology for hair follicle research and alopecia treatment, reporting no new clinical results but highlighting future research directions.

In this study, female rats given high doses of testosterone showed decreased endometrial thickness and lower mRNA levels of components in the LIF signalling pathway, indicating that excessive testosterone may negatively impact endometrial receptivity and potentially affect fertility.

In this study, researchers found that overexpression of LncRNA RP11-818O24.3 in hair follicle stem cells promotes their proliferation, self-renewal, and differentiation while inhibiting apoptosis through the FGF2-mediated PI3K/AKT signaling pathway, suggesting potential therapeutic applications for hair loss treatment.

This study concluded that KLF4 is a crucial regulator of hair follicle stem cell quiescence and may work by interacting with multiple transcription factors to control related genes.

This study introduces ficlatuzumab, an anti-HGF monoclonal antibody, in combination with gefitinib in a phase 2 trial to address EGFR TKI resistance in Asian NSCLC patients.