1398 citations
,
May 2008 in “Histochemistry and Cell Biology” This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.
1160 citations
,
November 2018 in “Physiological Reviews” This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
532 citations
,
August 2011 in “Journal of the American Academy of Dermatology” This article discusses the clinical presentation, histopathologic findings, and pathogenesis hypotheses of vitiligo without reporting new clinical results.
438 citations
,
October 2010 in “Oncogene” This review discusses the role of keratins in epithelial cell stress protection and cancer, highlighting their potential as multifunctional regulators and diagnostic markers, without presenting new research findings.
434 citations
,
October 2003 in “PTR. Phytotherapy research/Phytotherapy research” This review discusses the use of natural products in cosmetic preparations for skin and hair care, but reports no new research results.
425 citations
,
January 2021 in “SN Applied Sciences” This article highlights the versatility and potential of alginate and its derivatives in tissue engineering applications, discussing their properties, modification techniques, and various uses in enhancing tissue healing, bone regeneration, and cell growth.
416 citations
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September 1997 in “Journal of Investigative Dermatology” People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
411 citations
,
April 2010 in “Gastroenterology” This review explores various theories of colorectal cancer stem cell biology and highlights the need for better identification and targeting of these cells to advance treatment strategies, but reports no new clinical findings.
402 citations
,
August 2011 in “Cancer research” This study found that castration-resistant prostate cancers resistant to CYP17A1 inhibitors may still depend on steroids and could respond to therapies targeting de novo intratumoral steroid synthesis.
401 citations
,
January 2013 in “Postepy Dermatologii I Alergologii” This review discusses the biology and development of skin melanocytes, but reports no new clinical findings.
350 citations
,
June 1989 in “The American Journal of Medicine” This study suggests that itraconazole may significantly improve therapy for aspergillosis, with 12 out of 15 evaluable patients responding to the treatment.
340 citations
,
September 2014 in “PLOS Genetics” This study found that while genetic ancestry affects physical appearance traits in Latin American populations, it accounts for only a modest portion of the observed variation.
336 citations
,
August 2015 in “European Journal of Epidemiology” This article reviews the design and objectives of the Rotterdam Study, as well as summarizes major findings, without reporting new results.
308 citations
,
December 2018 in “PLOS Genetics” This study identified three novel genetic loci associated with PCOS and found similar genetic architecture across different diagnostic criteria, with evidence suggesting genetic links between PCOS and various metabolic and psychological traits.
305 citations
,
February 2007 in “Hormone and metabolic research” This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.
295 citations
,
September 2006 in “Cell Cycle” This review discusses the role of the TOR pathway in aging and suggests that rapamycin could potentially target age-related diseases, but reports no new clinical results.
293 citations
,
November 2011 in “Nature” This study found that the circadian clock regulates the activation state of murine epidermal stem cells, affecting tissue homeostasis and susceptibility to tumorigenesis when disrupted.
284 citations
,
February 2008 in “Pediatrics” This review discusses the potential impact of endocrine-disrupting chemicals and body size on pubertal onset and progression, highlighting critical gaps and priorities for future research without presenting new clinical results.
284 citations
,
November 1999 in “Neurology” This article discusses the side effects of interferon beta therapy for MS, including flu-like symptoms and autoimmune reactions, and provides guidance on their management but does not report new clinical findings.
277 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.
269 citations
,
May 2002 in “Journal of Neuroscience” This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.
266 citations
,
November 2013 in “European Journal of Epidemiology” This article outlines the rationale and design of the Rotterdam Study, summarizes its major findings, and updates its objectives and methods; it reports no new research results.
258 citations
,
July 2016 in “Reproductive Biology and Endocrinology” This abstract reviews the characteristics and health risks associated with polycystic ovary syndrome and does not report new findings, highlighting the syndrome's multifactorial nature.
253 citations
,
April 2014 in “Drugs” This review discusses the preclinical and clinical data on teriflunomide for multiple sclerosis, highlighting its selective action on immune cells without causing clinical immune suppression, and provides no new clinical results.
252 citations
,
April 2009 in “Seminars in Cell & Developmental Biology” This review discusses the complex role of the immune system in tissue repair and regeneration, highlighting its positive and negative influences but reports no new clinical findings.
245 citations
,
March 2012 in “Journal of The American Academy of Dermatology” This review discusses the dermoscopic features of common hair and scalp disorders and reports no new clinical results, aiming to assist dermatologists in diagnosing conditions like tinea capitis and alopecia areata.
242 citations
,
February 2016 in “Science” This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.
237 citations
,
February 2016 in “Science Translational Medicine” This study found that many effects previously thought to be caused by circadian rhythm disruption in Bmal1 knockout mice are actually due to BMAL1's properties unrelated to its clock function.
233 citations
,
November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This review explores androgen metabolism in the skin, highlighting enzyme localization and potential implications for treating androgen-dependent skin conditions, but it reports no new clinical results.
228 citations
,
January 2021 in “Journal of Neuroimmune Pharmacology” This review explores possible reasons for why male COVID-19 patients experience more severe symptoms and higher fatality rates than female patients but provides no new clinical results.