29 citations
,
July 2012 in “Fertility and Sterility” This study observed that hepatotoxicity is a rare but possible event in hyperandrogenic young females treated with low- and ultralow-dose flutamide, regardless of dose or oral contraceptive use.
28 citations
,
March 2017 in “Scientific Reports” This study found that minoxidil may protect against chemotherapy-induced peripheral neuropathy and potentially support hair recovery and tumor suppression in mouse models.
28 citations
,
August 2014 in “Cancer Causes & Control” In this study, there was no evidence that using 5α-reductase inhibitors for either short or long durations increased the risk of male breast cancer.
28 citations
,
September 2008 in “Current Pharmaceutical Design” This review discusses hypersensitivity reactions to anticoagulants like ASA and heparins, highlighting their rare but potentially life-threatening nature, and emphasizes the need for meticulous allergy testing to find safe alternatives.
27 citations
,
July 2017 in “European Journal of Dermatology” This article reviews the role of microRNAs as epigenetic modulators in dermatology but reports no new clinical findings.
27 citations
,
January 2017 in “Neuropsychopharmacology” This study found that acute sleep deprivation enhanced 5α-reductase expression and activity in the rat prefrontal cortex, and finasteride treatment reduced associated psychosis- and mania-like behaviors.
27 citations
,
May 2008 in “Neuroscience” This study found that altering neonatal neurosteroid levels affected anxiety and aversive learning in adult rats, possibly through changes in hippocampal GABAergic functions.
26 citations
,
December 2019 in “Neurobiology of Stress” This review discusses adverse effects of 5 alpha-reductase inhibitors, particularly persistent side effects such as post-finasteride syndrome, and highlights the need for further investigation.
26 citations
,
January 2013 in “BioMed Research International” This review discusses the hormonal influences on hair cycling disorders in post-partum and postmenopausal women and notes the lack of evidence for effective targeted treatments.
25 citations
,
October 2019 in “JAAD Case Reports” This article discusses the role of interleukin-15 and Janus kinase inhibitors in alopecia areata based on a murine model and reports no new experimental results.
24 citations
,
January 2014 in “The American Journal of Chinese Medicine” This review compiles data on Platycladus orientalis leaves, noting their diverse pharmacological activities and advocating for more research to clarify their traditional blood-cooling and hematostatic uses.
24 citations
,
June 2011 in “Andrologia” This study found that Ganoderma lucidum extracts reduced prostate enlargement and improved symptoms in testosterone-treated rats, suggesting potential benefits for managing benign prostatic hyperplasia.
24 citations
,
May 2009 in “Veterinary Dermatology” This review discusses the dermatology of nonhuman primates and emphasizes the need for a cohesive approach to study and report their dermatologic diseases, without assuming similarities to human or other veterinary conditions.
24 citations
,
March 1995 in “British Journal of Dermatology” This study reported that etretinate treatment leads to increased hair shedding due to a sustained decrease in anagen duration, with an arrest at the onset of anagen and a follicular anchorage defect in telogen contributing to alopecia.
23 citations
,
May 2013 in “Virology” This study found that HPV16 oncogene expression in multipotent epithelial stem cells led to abnormal mobilization, altering their quiescence without affecting other stem cell markers, suggesting a distinct stem cell compartment.
22 citations
,
October 2018 in “Aesthetic Plastic Surgery” This review discusses the latest understanding of androgenetic alopecia, including stem cell niches in hair follicles, and highlights emerging treatments like growth factors and platelet-rich plasma without new clinical findings.
22 citations
,
June 2018 in “Journal of Neuroinflammation” This study found that procyanidins effectively alleviate neuropathic pain in mice by significantly inhibiting MMP-9/2 activity.
21 citations
,
January 2006 in “Pediatrics” This review discusses how certain genetic, infectious, and metabolic conditions might influence disease severity and highlights the potential for new therapies, but it presents no new research findings.
20 citations
,
November 2019 in “Biomolecules” This study found that finasteride impaired stress reactivity and reduced exploratory and impulsive behaviors in rats, potentially by altering the hypothalamus-pituitary-adrenal axis function.
20 citations
,
September 2016 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses the addition of skin cancer caused by UV irradiation to the list of occupational diseases in Germany and reports no new clinical results.
20 citations
,
February 1991 in “Archives of dermatology” In this study, researchers found that high-dose tryptophan ingestion before symptom onset may be linked to clinical features resembling eosinophilia-myalgia syndrome in patients with eosinophilic fasciitis.
19 citations
,
December 2015 in “European Journal of Human Genetics” This study found that a novel rare variant in ITGB6 may cause intellectual disability, alopecia, and dentogingival anomalies in a specific Pakistani family, highlighting a potential role for ITGB6 beyond enamel formation.
19 citations
,
October 2013 in “Headache: The Journal of Head and Face Pain” This review discusses conventional and alternative treatments for trigeminal autonomic cephalalgias, including cluster headache, paroxysmal hemicrania, and SUNCT, and recommends specific medications without reporting new clinical findings.
19 citations
,
October 2008 in “Journal der Deutschen Dermatologischen Gesellschaft” This article reviews the cutaneous reactions and characteristic skin changes associated with chemotherapy, radiation therapy, and new targeted cancer treatments, reporting no new clinical results.
18 citations
,
June 2008 in “Archives of Dermatology” This study found that a 60-second hair count is a reliable and consistent method to assess hair shedding in healthy men without alopecia.
18 citations
,
March 2006 in “Expert Review of Neurotherapeutics” This review outlines strategies for preventing, identifying, and managing complications related to current MS therapies and reports no new clinical results, emphasizing the growing complexity in MS treatment regimens.
18 citations
,
January 1999 in “CNS Drugs” This review discusses challenges in managing cutaneous drug reactions to anticonvulsants and reports no new clinical findings; the authors emphasize the complexity of discontinuing or rechallenging suspected agents.
17 citations
,
June 2021 in “Molecules” This review summarizes the promising role of melatonin combined with nanosized carriers in drug delivery, suggesting enhanced effectiveness in treating various diseases compared to free melatonin.
17 citations
,
April 2015 in “Tropical Journal of Pharmaceutical Research” This review highlights the traditional use and potential therapeutic activities of Asiasari Radix in drug discovery, but it reports no new clinical results.
17 citations
,
March 2012 in “The Journal of Pathology” This article argues that lineage labeling with genetic markers is the gold standard for identifying epithelial stem cells, contrary to the view that in vitro methods alone are sufficient.