November 2024 in “Health Science Reports” This systematic review found that light and laser therapies, including excimer and erbium-glass lasers, generally increase hair density and diameter in various types of alopecia, with particularly notable effects in androgenic alopecia but limited efficacy in telogen effluvium.
147 citations
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January 2014 in “American Journal of Clinical Dermatology” This study found that low-level laser treatment with the HairMax Lasercomb significantly increased terminal hair density in both men and women with pattern hair loss, with no serious adverse events reported.
26 citations
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January 2012 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This article reviews light-based hair removal devices for home use, highlighting safety issues and the need for consistent international regulations and guidelines for their manufacture and marketing.
11 citations
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January 2020 in “Skin appendage disorders” This study reviewed clinical trials and found that low-level laser therapy significantly increased hair diameter or density in both men and women with pattern hair loss compared to a sham device, though the involvement of industry relationships in some studies suggests cautious interpretation.
4 citations
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August 2022 in “Lasers in medical science” In this study, both 1565-nm non-ablative fractional laser and long-pulsed 1064-nm Nd:YAG laser effectively reduced enlarged facial pores, with no significant difference in efficacy and minimal side effects, though the Nd:YAG laser had less severe side effects.
1 citations
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November 2023 in “Journal of Cutaneous and Aesthetic Surgery” This study found that diode laser effectively reduces unwanted facial hair in darker skin types and reported no serious adverse events, suggesting that trichoscopy is an underutilized tool for assessing laser hair reduction outcomes.
July 2026 in “Journal of the Pakistan Medical Association” This study found that combining topical eflornithine with triple diode laser treatments in women with hirsutism led to a more rapid and nearly complete reduction of terminal hair after 6 months, though the intergroup differences were not significant at 6- and 12-month follow-ups.
June 2026 in “Lasers in Medical Science” This randomized trial found that diode laser achieved more favorable long-term hair removal outcomes but induced more discomfort and transient adverse effects compared to intense pulsed light in women with Fitzpatrick skin types I-IV.
May 2024 in “Lasers in medical science” In this retrospective study, a combined therapy of ablative fractional Er: YAG laser and medication was more effective in treating male androgenetic alopecia than medication alone, without causing serious adverse effects, as evaluated over 24 weeks.
August 2025 in “Lasers in Medical Science” In this study, the combination of low-level laser therapy and topical minoxidil was found to improve hair density and diameter more effectively than minoxidil alone in treating androgenic alopecia, with similar safety profiles observed in both groups.
21 citations
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January 2018 in “Lasers in Medical Science” This study concluded that 12 sessions of fractionated thulium laser treatment improved hair density and thickness in patients with pattern hair loss, with further benefits from adding a growth factor solution post-treatment.
9 citations
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July 2022 in “Dermatology and Therapy” In this study, long-pulsed 755-nm alexandrite laser treatment for keratosis pilaris significantly improved skin roughness and redness, as well as follicular plug reduction, with good safety and patient satisfaction compared to a moisturizing lotion alone.
May 2026 in “Journal of Cosmetic Dermatology” This meta-analysis found that fractional laser therapy significantly improved hair density in patients with androgenetic alopecia and exhibited a favorable safety profile, with mild to moderate adverse events. Combination therapy with laser and other treatments was more effective than other treatments alone.
November 2023 in “Deleted Journal” In this study, the researchers found no superiority of combining 308-nm excimer laser with intralesional corticosteroid over corticosteroid alone for treating frontal fibrosing alopecia, and reported side effects such as erythema and postinflammatory hyperpigmentation in both treatment groups.
June 2023 in “Dermatology and Therapy” This study found that for patients with moderate-to-severe chronic hand eczema, combining fractional CO2 laser with halometasone cream was more effective than using halometasone cream alone, with a higher treatment success rate and fewer relapses, though skin pigmentation was a common side effect.
21 citations
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December 2022 in “Pharmaceutics” This review found that laser-assisted drug delivery in humans was associated with several adverse effects, but no life-threatening events were reported in the studies examined.
29 citations
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April 2019 in “Lasers in Medical Science” This study found that combining fractional erbium-glass laser therapy with topical minoxidil significantly improved hair density and diameter in men with androgenetic alopecia compared to using minoxidil alone over a 24-week period, with no serious adverse events reported.
11 citations
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January 2022 in “Journal of Healthcare Engineering” In this study, PRP and Yifu combined with ultrapulsed CO2 lattice laser were found to improve sunken acne scars more effectively than laser alone, enhancing patients' quality of life and reducing adverse events, with a higher effective rate compared to the laser-only group.
8 citations
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January 2023 in “Skin Research and Technology” This study found that treatment with fractional 1064 nm picosecond Nd:YAG laser effectively reduced post-acne erythema in adult Chinese patients without causing scarring or pigmentation issues, though some experienced temporary erythema, oedema, pruritus, and acne eruptions.
1 citations
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January 2023 in “Journal of cosmetic dermatology” The study found that CO2 dot matrix laser combined with platelet-rich plasma improved scar repair, psychological state, and quality of life in patients with acne vulgaris-related depressed scars.
February 2026 in “International Journal of Basic & Clinical Pharmacology” This study found that hair rejuvenation therapies and patient comorbidities, such as diabetes mellitus, were significantly associated with adverse drug reactions in cosmetic treatment recipients.
January 2025 in “Dermatologic Therapy” This study found that ablative fractional carbon dioxide laser treatment improved skin fibrosis, reduced skin hardening, and enhanced hair follicle growth in localized scleroderma patients, with significant improvements across several clinical measures and no severe adverse effects observed.
February 2022 in “INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH” This study reviewed 44 clinical trials and found that home-based laser devices are effective for short-term hair removal and skin rejuvenation, with common side effects including erythema and edema; additional trials are needed to confirm safety and efficacy.
January 2019 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology” This study suggests that low level laser therapy may be effective for alopecia compared to placebo, but current evidence is limited and studies show a high risk of bias.
19 citations
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August 2018 in “Journal of the American Academy of Dermatology” In this study, the researchers found that the picosecond pulsed alexandrite laser (PSAL) may be as effective and safe as the Q-switched alexandrite laser (QSAL) for treating freckles in Chinese patients.
7 citations
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August 2024 in “Skin Research and Technology” The study's findings are unreliable due to retraction.
21 citations
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January 2007 in “Journal of Drugs in Dermatology” This study found that the 3-msec alexandrite laser effectively reduced unwanted, pigmented hair in individuals with skin types IV and V, but was less safe in those with skin type VI.
5 citations
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August 2022 in “Mediators of Inflammation” This study found that combining pulsed dye laser with pingyangmycin improved treatment efficacy, scar repair, skin condition, and patient satisfaction in treating post-acne hyperplastic scars, compared to laser alone, without increasing adverse reactions.
January 2026 in “Dermatologic Therapy” In this prospective study, individuals with androgenetic alopecia using a home-use low-level laser therapy helmet for 48 weeks experienced significant increases in hair density and thickness, with reported improvements consistent across sexes and no device-related adverse events.
January 2026 in “Dermatologic Therapy” This study found that combining ablative fractional CO2 laser treatment with topical minoxidil significantly improved frontal hairline regrowth and patient satisfaction in men with androgenetic alopecia compared to using minoxidil alone, without serious adverse effects.