research Cost-Effectiveness of Palliative Chemotherapy in Advanced Gastrointestinal Cancer
Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.
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research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling
Cathepsin L is essential for normal hair growth and development.
research Polymorphisms of the Androgen Receptor Gene and the Estrogen Receptor Beta Gene Are Associated with Androgen Levels in Women
Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.
research Metformin Improves Polycystic Ovary Syndrome Symptoms Irrespective of Pre-Treatment Insulin Resistance
Metformin helps with PCOS symptoms no matter the patient's initial insulin resistance or weight.
research Learning From Nudity: Lessons From The Nude Phenotype
The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
research Topical Janus Kinase Inhibitors for the Treatment of Pediatric Alopecia Areata
Topical JAK inhibitors may help children with alopecia areata regrow hair.
research Androgen Excess: Investigations and Management
The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.
research RASopathic Skin Eruptions During Vemurafenib Therapy
Vemurafenib causes skin side effects similar to RASopathies, requiring regular skin checks and UVA protection.
research Keratinocyte-Specific Ablation of the NF-κB Regulatory Protein A20 (TNFAIP3) Reveals a Role in the Control of Epidermal Homeostasis
A20 protein is crucial for normal skin and hair development.
research The Skin POMC System (SPS): Leads and Lessons from the Hair Follicle
The Skin POMC System affects hair growth and skin responses to stress.
research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling
Blocking BMP signaling causes hair loss and disrupts hair growth cycles.
research What Should It Take to Describe a Substance or Product as 'Sperm-Safe'?
Products should be called 'sperm-safe' only after thorough, well-designed tests.
research FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice
The Foxn1 gene is essential for normal nail and hair development.
research Long-Term Post-COVID Symptoms and Associated Risk Factors in Previously Hospitalized Patients: A Multicenter Study
Most hospitalized COVID-19 patients had long-term symptoms like fatigue and hair loss, with women and those sicker during hospitalization at higher risk.
research Proliferative and Non-Proliferative Lesions of the Rat and Mouse Integument
The project created a standardized system for classifying skin lesions in lab rats and mice.
research Effects of a Low-Dose Desogestrel-Ethinylestradiol Combination on Hirsutism, Androgens, and Sex Hormone Binding Globulin in Women with Polycystic Ovary Syndrome
Low-dose oral contraceptives reduced hair growth and testosterone levels in women with polycystic ovary syndrome.
research Acquired Zinc Deficiency Dermatosis in Humans
Zinc supplements can resolve skin issues caused by zinc deficiency.
research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia
Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.
research The Psychosocial Burden of Alopecia Areata and Androgenetic Alopecia: A Cross-Sectional Multicentre Study Among Dermatological Outpatients in 13 European Countries
People with hair loss conditions experience more anxiety, depression, and a lower quality of life than those without these conditions.
research Medical Education and Care in Dermatology During the SARS-CoV-2 Pandemic: Challenges and Opportunities
The pandemic has pushed dermatology education and care to adopt digital solutions, which are effective and likely to continue post-pandemic.
research Transient Efficacy of Tofacitinib in Alopecia Areata Universalis
Tofacitinib temporarily regrew hair in a man with alopecia, but its effects didn't last.
research Dermoscopy: What's New?
Dermoscopy has improved skin cancer diagnosis and has expanding applications in dermatology, but requires staying updated with new research and techniques.
research A Primer for Studying Cell Cycle Dynamics of the Human Hair Follicle
The document concludes that understanding hair follicle cell cycles is crucial for hair growth and alopecia research, and recommends specific techniques and future research directions.
research Effects of Finasteride on Vascular Endothelial Growth Factor
Finasteride reduces prostate bleeding by affecting blood vessel growth.
research Male-Pattern Hair Loss in Norwegian Men: A Community-Based Study
Hair loss common in Norwegian men, affecting self-esteem and life quality.
research Effect of Hyaluronic Acid and Poly-L-Lactic Acid Dermal Fillers on Collagen Synthesis: An In Vitro and In Vivo Study
Hyaluronic acid increases collagen synthesis safely, while poly-L-lactic acid may cause complications by affecting fibroblasts.
research Lichen Planus and Other Cutaneous Manifestations in Chronic Hepatitis C: Pre- and Post-Interferon-Based Treatment Prevalence in a Cohort from a Low Hepatitis C Virus Endemic Area
Skin problems like itching, dry skin, and hair loss are more common in hepatitis C patients after interferon treatment, but lichen planus is not linked to the infection.
research Effects of Cyclosporine A on Clinical and Histologic Abnormalities in Dogs with Sebaceous Adenitis
Cyclosporine A can reduce inflammation in dogs with sebaceous adenitis, but ongoing treatment is needed.
research The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men
St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.
research IL-36γ Drives Skin Toxicity Induced by EGFR/MEK Inhibition and Commensal Cutibacterium Acnes
A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.