research Clinicopathological Characteristics of Fibrosing Alopecia in a Pattern Distribution: A Single-Center, Retrospective Study
The study suggests fibrosing alopecia in a pattern distribution has distinct features and may vary by race.
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450-480 / 644 results research Epidermal Barrier
Healthy skin prevents water loss and protects against threats.
research Efficient In Vitro Transfection of Human Keratinocytes with an Adenovirus-Enhanced Receptor-Mediated System
The study investigated three nonviral transfection systems for gene transfer in human keratinocytes, with a focus on the adenovirus-enhanced receptor-mediated (AVET) system. The AVET system showed superior efficiency, achieving a transfection rate of 28.8%, compared to lower rates with SuperFect and no success with PrimeFector. The presence of adenovirus was crucial for effective gene delivery. The study also found that slowly adhering keratinocytes were transfected more effectively, suggesting stem cells were less efficiently transfected. The AVET system was able to correct the enzymatic defect in keratinocytes from lamellar ichthyosis patients, but was unsuccessful in organotypic cultures due to barriers like the cornified layer. Overall, the AVET system was a powerful tool for transient in vitro transfection of keratinocytes, with potential applications in gene therapy for skin diseases.
research Cutaneous Adnexal Cysts Revisited: A Novel Classification Based on Morphological and Molecular Features
The conclusion introduces a new way to classify skin cysts using their shape and genetic markers.
research Netherton's Syndrome: A Syndrome of Elevated IgE and Characteristic Skin and Hair Findings
Netherton's syndrome is linked to high IgE levels and unique skin and hair symptoms, and may improve with ammonium lactate lotion and allergy management.
research A Novel Technique for Repositioning Lower Eyelid Fat via the Transoral Approach in Association with Midface Lift
The new technique for repositioning lower eyelid fat with a midface lift is easier, faster, and has better results with fewer complications.
research Mapping of a Novel Locus for Keratosis Follicularis Squamosa on Chromosome 7p14.3–7p12.1
A new gene location for Keratosis follicularis squamosa was found on chromosome 7p14.3-7p12.1.
research Clinical Investigation of JAK Inhibitor Tofacitinib in Scarring Alopecias
Tofacitinib may slow hair loss in scarring alopecias but is unlikely to regrow significant hair.
research Effect of Disulfide Bonds in Human Hair Fibers on the Melting Behavior of Their Crystalline Structure
Disulfide bonds affect the melting behavior of hair's crystalline structure, but hair retains some stability even after these bonds are broken.
research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation
TCDD speeds up skin barrier formation by increasing certain gene expressions.
research Niosomes as a Promising Carrier for Topical Drug Delivery
Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.
research Effect of Ethnicity and Treatments on In Situ Tensile Response and Morphological Changes of Human Hair Characterized by Atomic Force Microscopy
Different ethnicities and treatments affect human hair strength and structure.
research Lash Ptosis in Congenital and Acquired Blepharoptosis
Lash ptosis is more common and severe in people with congenital eyelid droop than in those with acquired eyelid droop or without eyelid droop.
research Effect of Ethosomal Minoxidil on Dermal Delivery and Hair Cycle of C57BL/6 Mice
Ethosomal minoxidil improves hair growth by penetrating deeper into skin and shortening hair cycle.
research Cross-Linked Features of Mouse Pelage Hair Resistant to Detergent Extraction
Some mutant mice have hair with abnormal cross-linking, mainly in the cuticle, not affecting other hair parts.
research Niosomal Delivery of Pumpkin Seed Oil: Development, Characterization, and Physical Stability
The pumpkin seed oil niosomes are promising for skin and hair treatments because they are stable and effectively deliver the oil.
research Cutaneous Adnexal Cysts Revisited: What We Know and What We Think We Know
A new classification system for skin cysts was proposed to improve diagnosis.
research Equine Hoof Stem Progenitor Cells (HPC) CD29+/Nestin+/K15+ – A Novel Dermal/Epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment
Newly found stem cells in horse hooves show promise for treating a hoof disease called laminitis.
research Contact Dermatitis Associated with Alopecia and Hyperpigmentation
Avoiding allergens can improve skin and hair conditions in adults with allergic reactions.
research Canine Alopecia X-Like Disorder
The dog likely has a condition similar to Canine alopecia X.
research Exploring the Effects of Wetting and Free Fatty Acid Deposition on a Hair Fiber Surface Model Incorporating Keratin Associated Protein 5-1
Water and fatty acids affect hair's surface differently based on hair damage, and models can help understand hair-cosmetic interactions.
research In This Issue
Scientists found a new method using 3D cell cultures to grow human hair which may improve hair restoration treatments.
research Fibrosing Alopecia in a Pattern Distribution
Fibrosing alopecia in a pattern distribution is a unique hair loss condition with inflammation and scarring, resembling but distinct from common balding.
research Immunology and Genetics
The document concludes that Borrelia afzelii causes a skin condition in France, a gene is linked to hair loss in Caucasian women, and various genetic mutations affect skin diseases.
research Corrections to 'Female Pattern Hair Loss and Its Relationship to Permanent/Cicatricial Alopecia: A New Perspective'
Title change to "Central Centrifugal Cicatricial Alopecia (CCCA)"; common in African American women; hair-grooming methods may contribute; no effective therapy found; trials needed.
research Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery
Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.
research Female Pattern Hair Loss
Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.
research Lecithin Organogels as a Potential Phospholipid-Structured System for Topical Drug Delivery: A Review
Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.
research Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes
Liposomes and niosomes improve finasteride delivery for hair loss treatment.
research Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site Distinct from the Legumain-binding Site
Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.