36 citations
,
February 2011 in “Fertility and Sterility” This case report suggests that discontinuing low-dose finasteride in a 48-year-old man led to a significant reduction in sperm DNA fragmentation index, indicating a possible link between finasteride and sperm DNA damage.
35 citations
,
November 2020 in “Experimental Dermatology” This study found that upper wound fibroblasts are crucial for hair follicle regeneration during wound healing and suggests that these cells, along with papillary fibroblasts, migrate within the wound.
35 citations
,
July 2018 in “Cell Reports” This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.
34 citations
,
July 2010 in “Expert Opinion on Drug Delivery” This review highlights the need for methodologies to understand and quantify drug penetration into hair follicles as significant drug pathways, noting this area lacks comprehensive articles and reports no new results.
34 citations
,
January 1989 in “Toxicologic Pathology” This study observed that minoxidil induced myocardial necroses and hemorrhages in beagle dogs and miniature swine, with greater severity seen in dogs.
33 citations
,
November 2014 in “Military Medicine” This retrospective review of the U.S. military's teledermatology program from 2004 to 2012 found that timely consultations helped avoid unnecessary medical evacuations and facilitated necessary ones for service members and coalition partners.
33 citations
,
December 2013 in “Journal of cutaneous pathology” A fungal infection can look like a different scalp condition in teens, leading to wrong treatment until proper tests are done.
31 citations
,
May 2015 in “Stem Cell Reports” This research discusses a novel imaging approach in live mice to study stem cell and niche interactions in tissue homeostasis and reports no new results.
30 citations
,
June 2017 in “Talanta” This review discusses the critical parameters for MALDI IMS sample preparation in skin analysis and highlights its applications in wound healing, neoplasia, and infection research, but reports no new clinical results.
30 citations
,
March 2015 in “PLoS ONE” This study found that thyroxine modulates peripheral molecular clock gene expression in human hair follicles, which may have implications for treating clock-related diseases in patients with thyroid dysfunction.
30 citations
,
May 2005 in “Pediatric dermatology” This report reviews familial cases of aplasia cutis of the scalp, noting large irregular defects at the vertex or anterior along the sagittal suture in six families.
29 citations
,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that Merkel cell clusters require Frizzled6 signaling for their polarity information, while other hair follicle-associated structures align their orientation based on the hair follicle itself.
28 citations
,
July 2002 in “Dermatologic Surgery” This study found that improved outcomes in scalp surgery were achieved by utilizing knowledge of the surgical anatomy of the scalp to avoid complications like unsightly scars and distorted hair patterns.
28 citations
,
February 1999 in “Archives of Dermatological Research” Finasteride potentially treats hair loss by reducing DHT production.
28 citations
,
March 1987 in “Journal of The American Academy of Dermatology” This study observed that two out of twelve patients showed hair growth without the usual shedding after hair transplant surgery when treated with topical minoxidil, suggesting its potential as an adjunctive therapy during recovery.
25 citations
,
July 2021 in “Journal of Medical Virology” This review focuses on the various skin symptoms associated with COVID-19 but reports no new clinical findings.
25 citations
,
May 2011 in “Annals of Plastic Surgery” This study reported that follicular unit extraction using nonhead hair sources like the chest or beard may successfully restore hair density and achieve aesthetically pleasing results in severely bald men with limited head donor hair.
25 citations
,
March 2009 in “Dermatologic Surgery” This abstract contains no specific study findings, results, or conclusions to summarize.
25 citations
,
May 1986 in “The American Journal of the Medical Sciences” In this study, 53% of patients with male pattern baldness experienced significant hair growth with one year of topical minoxidil, while 95% rated its effectiveness as moderate or excellent.
24 citations
,
January 2015 in “Annals of Dermatology” In this study, herbal extracts commonly used in traditional medicine were observed to significantly increase the proliferation of human dermal papilla cells, suggesting potential as alternative therapies for enhancing hair growth.
24 citations
,
November 2013 in “Trends in pharmacological sciences” This article describes a potential novel approach to reduce chemotherapy-induced hair loss by enhancing the expression of specific transporters in hair follicles, but reports no clinical results.
24 citations
,
May 2012 in “International Journal of Dermatology” This review discusses the various causes and associations of eyelash trichomegaly, including congenital syndromes, acquired conditions, and drug effects, without reporting new clinical results.
24 citations
,
May 2006 in “Proceedings of the National Academy of Sciences of the United States of America” This study reported that heterozygosity for FHIT affects mice's susceptibility to spontaneous alopecia areata and to certain preneoplastic lesions induced by benzo[a]pyrene, but does not change how they respond to budesonide and N-acetyl-L-cysteine.
24 citations
,
March 2001 in “Journal of Endocrinology/Journal of endocrinology” In this study, androgen receptors were found only in the mane follicles of red deer stags during the breeding season, suggesting their expression is induced by seasonal hormone changes.
24 citations
,
May 1982 in “Biochemical Pharmacology” These drugs cause hair growth without affecting testosterone or adrenal hormones.
23 citations
,
January 2021 in “Scientific Reports” In this study, hair follicle germs containing vascular endothelial cells showed improved hair regeneration and morphogenesis-related gene expression in mice, suggesting a promising strategy for hair regenerative medicine.
23 citations
,
December 2013 in “British Journal of Dermatology” This study identified a new PNPLA1 mutation in a Spanish family with autosomal recessive congenital ichthyosis.
23 citations
,
September 2009 in “Child Abuse & Neglect” This case report highlights the importance of considering hair-thread tourniquet syndrome as a potential diagnosis for girls with genital swelling and pain, emphasizing the need for prompt intervention.
23 citations
,
July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that follicular stem cells in hair follicles are more sensitive to the antiproliferative effects of glucocorticoids compared to basal keratinocytes due to incomplete desensitization.
23 citations
,
August 1987 in “Australasian Journal of Dermatology” In these studies, among 326 geriatric patients in Ottawa, the most common skin complaints were actinic keratoses, eczema, benign tumors, and malignant tumors.