23 citations
,
July 1989 in “Postgraduate medical journal” This study found that spironolactone 100 mg daily did not demonstrate objective benefits in managing idiopathic hirsutism, as it increased hair shaft diameter without reducing serum androgen levels.
23 citations
,
September 2017 in “Journal of the American Academy of Dermatology” This article hypothesizes that apremilast, a phosphodiesterase 4 inhibitor, could be a targeted treatment for alopecia areata due to its ability to suppress interferon-gamma production, but reports no new clinical results.
23 citations
,
April 2010 in “Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology” This study found that exposure to sex steroid biosynthesis inhibitors increases the expression of piRNA pathway genes in frog larvae, suggesting these genes play a role in gonadal sex differentiation.
22 citations
,
September 2014 in “Veterinary Dermatology” This study found that low-level laser therapy may have promising effects on hair regrowth in dogs with noninflammatory alopecia, with most animals showing improvement after treatment.
22 citations
,
June 2002 in “Seminars in cutaneous medicine and surgery” This review discusses the use of laser and flashlamp technology for unwanted hair removal and reports no new clinical results, highlighting challenges with light-colored hair and treatment safety for darker skin tones.
22 citations
,
September 2022 in “Medicina” This study found that the dual-wavelength non-ablative fractional laser provides enhanced skin rejuvenation by increasing thermal lesion coverage and collagen remodeling compared to using the CO2 laser alone in an ex vivo setting.
22 citations
,
October 2007 in “Journal of Investigative Dermatology” Stem cells in mouse nails are found in the nail matrix and may control nail growth.
21 citations
,
January 2019 in “Lasers in Medical Science” This review found that low-level laser therapy significantly increased hair density in adults with androgenic alopecia compared to sham treatments, with greater effects observed at lower treatment frequencies.
21 citations
,
December 2022 in “Pharmaceutics” This review found that laser-assisted drug delivery in humans was associated with several adverse effects, but no life-threatening events were reported in the studies examined.
21 citations
,
April 2019 in “Journal of cosmetic and laser therapy” This review examines the devices, mechanisms, risks, side effects, and regulatory differences in laser hair removal, particularly highlighting the lack of regulation in South Africa and its implications for patient safety.
21 citations
,
January 2018 in “Lasers in Medical Science” This study concluded that 12 sessions of fractionated thulium laser treatment improved hair density and thickness in patients with pattern hair loss, with further benefits from adding a growth factor solution post-treatment.
21 citations
,
January 2015 in “Dermatologic Therapy” This letter discusses a case of erosive pustular dermatosis of the scalp linked to topical latanoprost use for androgenetic alopecia, but reports no clinical results.
21 citations
,
February 2012 in “Journal of the European Academy of Dermatology and Venereology” This study found that late-onset alopecia areata is more common in women and tends to present with milder symptoms, with some patients achieving complete hair regrowth in mild cases.
20 citations
,
July 2020 in “Expert Opinion on Biological Therapy” This study found that combining micro-needling, low-level laser therapy, and autologous non-activated platelet-rich plasma increased hair density in patients with androgenic alopecia over the treatment period.
20 citations
,
June 2020 in “Journal of Cosmetic Dermatology” This study found that hypoxia increases the proliferation of dermal papilla cells and highlighted the important role of lactate dehydrogenase in this process.
20 citations
,
April 2011 in “Dermatologic Surgery” Laser therapy helped new hair grow in scarred skin for three patients.
20 citations
,
November 2009 in “European Journal of Dermatology” This study found that topical latanoprost was not effective in treating alopecia areata in eyebrows and eyelashes.
20 citations
,
January 2005 in “Australasian Journal of Dermatology” This article describes a case of late-onset focal dermal elastosis in a 73-year-old woman, characterized by flat pale yellow lesions and increased normal elastic fibers, distinct from pseudoxanthoma elasticum.
20 citations
,
April 1999 in “British journal of plastic surgery” This study found that using a ruby laser for hair removal resulted in a significant average reduction of 56.4% in hair density among participants dissatisfied with other methods.
19 citations
,
December 2015 in “Journal of Materials Chemistry B” This study found that using layer-by-layer encapsulation techniques on dermal papilla cells can support their function and may help treat hair loss when used in conjunction with freshly isolated epidermal cells.
19 citations
,
December 2016 in “PLOS ONE” This study found that proteins secreted by early-passage dermal papilla cells, including SDF1, MMP3, biglycan, and LTBP1, may play significant roles in hair follicle regeneration.
19 citations
,
May 2016 in “Matrix Biology” In this mouse study, researchers found that the absence of laminin-511 in skin delays hair follicle development and disrupts hair shaft differentiation, affecting key transcription factors for hair keratins.
19 citations
,
August 2007 in “Seminars in Plastic Surgery” This review discusses five popular resurfacing technologies for facial rejuvenation, highlighting their role in achieving smoother, healthier, and younger-looking skin, and reports no new clinical results.
18 citations
,
December 2010 in “Journal of analytical atomic spectrometry” This study demonstrated that using lead-doped keratin film as a calibration standard allows for accurate tracking of lead distribution along hair strands, revealing different exposure patterns among workers in a battery manufacturing factory in Thailand.
18 citations
,
August 2018 in “Facial Plastic Surgery Clinics of North America” This review summarizes the positive clinical response of using platelet-rich plasma as an adjuvant in skin rejuvenation treatments, with no identifiable complications, suggesting a promising outlook for its future use.
18 citations
,
April 2014 in “Stem cells” The researchers reported that minor salivary gland stem cells exhibit stem cell characteristics and respond to tobacco-derived carcinogens, implicating the transforming growth factor beta pathway in their maintenance.
18 citations
,
May 2011 in “Journal of Investigative Dermatology” Wnt signaling affects the development and growth of Langerhans cells in mice.
18 citations
,
February 2023 in “Plants” This study found that PES1CMU-defatted rice bran (DFRB) showed effective skin whitening and anti-aging properties comparable to standard treatments in cell models, suggesting its potential use in dermatocosmetics.
18 citations
,
April 2019 in “Archives of Dermatological Research” This study found that bovine lactoferrin promotes hair growth in mice by enhancing dermal papilla cell proliferation through the Erk/Akt and Wnt signaling pathways.
18 citations
,
April 2016 in “Toxicological Research” This study found that lavender oil significantly promoted hair growth in female C57BL/6 mice by increasing hair follicle number, depth, and dermal thickness, while reducing mast cell numbers.