55 citations
,
November 2018 in “American journal of human genetics” This study identified five mutations in the gene LSS in individuals with unexplained hypotrichosis simplex, highlighting a potential role of mislocalized LSS proteins in disrupting hair follicle biology.
55 citations
,
March 2009 in “Journal of The American Academy of Dermatology” This study found that latanoprost and bimatoprost, when applied cutaneously to the eyelids, did not induce appreciable eyelash regrowth in patients with alopecia areata over 16 weeks.
53 citations
,
October 2012 in “Journal of dermatological treatment” This study found that low-fluence 1064 nm Q-switched Nd:YAG laser treatment effectively improved melasma in Asian patients without serious side effects, achieving an average improvement rate of 50-74%.
52 citations
,
June 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study defined menstrual phase-specific reference intervals for circulating androgen levels in young women, highlighting that anovulatory females showed higher androgen, LH, and FSH levels compared to ovulatory females.
51 citations
,
October 2002 in “Archives of dermatology” This case study of a patient with dissecting cellulitis of the scalp found that multiple medications, including isotretinoin, achieved only modest improvement, and symptoms returned after treatments were stopped.
50 citations
,
December 2010 in “Dermatologic Surgery” This study suggests that a 1,550-nm fractional erbium-glass laser may stimulate hair growth in both an alopecia mouse model and human subjects with male pattern hair loss, though further research is needed to determine its clinical applications.
50 citations
,
December 2009 in “Journal of The European Academy of Dermatology and Venereology” This study found that latanoprost may be effective for treating eyelash alopecia areata, achieving cosmetically acceptable regrowth in 45% of patients.
50 citations
,
February 2004 in “Genomics” This study identified a missense mutation in the rat Desmoglein 4 gene, causing abnormal hair shaft development in lanceolate hair mutant rats by disrupting a critical calcium binding site.
48 citations
,
March 2022 in “Nano Letters” This study suggests that sericin microneedles with antibacterial and directional traction functionalities may enhance infected wound healing by improving skin repair and inhibiting bacterial growth, indicating potential for clinical application.
48 citations
,
January 2014 in “Dermatology Online Journal” This review examines various treatments for dissecting cellulitis, noting isotretinoin may offer the best chance for remission despite limited long-term data and calls for more clinical studies.
47 citations
,
April 2016 in “Lasers in Surgery and Medicine” This review found that low-level laser therapy appears promising in improving hair regrowth and patient satisfaction in androgenetic alopecia, though results should be interpreted cautiously.
47 citations
,
November 2000 in “Archives of dermatology” In this observational study, the effectiveness of a diode laser was evaluated for treating pseudofolliculitis barbae at the Laser and Skin Surgery Center of New York, but it reports no new clinical results.
46 citations
,
May 2006 in “Laser Physics” In this study, particles similar in size to keratin cells were surprisingly found to penetrate more efficiently into hair follicles due to a possible pumping effect from moving hairs.
46 citations
,
December 2000 in “Seminars in Cutaneous Medicine and Surgery” This article discusses the use of lasers and light sources for hair removal and reports no new clinical results; it emphasizes the significance of selecting the appropriate laser system and treatment protocol for effective and safe outcomes.
45 citations
,
December 2018 in “Lasers in Medical Science” In a 24-week randomized trial, this study found that the RAMACAP laser helmet significantly increased hair density and diameter in androgenetic alopecia patients compared to a sham device, although limitations included a small sample size and potential issues with the control used.
45 citations
,
December 2004 in “Forensic Science International” This study reports that using laser microdissection to isolate telogen hair follicles significantly improves DNA extraction efficiency for STR typing, reducing contamination from keratin.
45 citations
,
August 1992 in “PubMed” In this study, researchers found that changes in the extracellular matrix components, particularly fibronectin, laminin, and type IV collagen, during the rat vibrissa follicle growth cycle, suggest dynamic remodeling related to dermal-epidermal signaling.
43 citations
,
June 2012 in “Lasers in Medical Science” In a rat model of chemotherapy-induced alopecia, this study found that low-level laser treatment significantly accelerated hair regrowth without affecting the efficacy of chemotherapy.
43 citations
,
September 2001 in “Scanning” Hair treatments like bleaching increase friction by exposing tiny pores on the hair surface.
43 citations
,
November 2012 in “Pharmaceutical research” This study found that fractional laser treatment significantly enhances the penetration and targeting of certain permeants, such as imiquimod and FD, to skin follicles, but not hydroquinone.
41 citations
,
December 2017 in “Lasers in Medical Science” This study found that low-level laser therapy may significantly improve androgenic alopecia in both men and women, either alone or alongside treatments like minoxidil and finasteride.
40 citations
,
April 2014 in “Genes & Development” The researchers reported that in mice, prolactin signaling in the skin epithelium inhibits hair follicle stem cell activation, promoting quiescence during periods of high serum prolactin like pregnancy and lactation.
40 citations
,
February 2012 in “Dermatology Online Journal” This review discusses cases and research on paradoxical hair growth after laser hair removal and explores laser and light therapies for treating alopecia, but reports no new results.
40 citations
,
September 2012 in “European Journal of Dermatology” This study found that long pulsed Nd-YAG laser treatment significantly improved acne keloidalis nuchae by reducing inflammation and hair follicles, with early intervention yielding the best results.
40 citations
,
May 2005 in “Journal of Cell Science” In this study, transgenic mice expressing a truncated form of latent transforming growth factor-β-binding protein exhibited altered hair cycles due to increased active transforming growth factor-β, impacting keratinocyte proliferation and hair cycle phases.
39 citations
,
January 2008 in “Journal of cosmetic and laser therapy” This review examines the literature on laser hair removal to provide evidence-based guidelines for treatment intervals, pre- and post-treatment practices, and areas that should be avoided, but presents no new findings.
39 citations
,
January 2006 in “Journal of Cosmetic and Laser Therapy” This study found that pneumatic skin flattening (PSF) significantly reduces pain and post-treatment erythema during high-energy IPL and laser hair removal while enhancing treatment efficacy.
39 citations
,
April 2001 in “Journal of The American Academy of Dermatology” This article reviews the side effects of topical latanoprost therapy, particularly the hypertrichosis and pigmentation changes of eyelashes and nearby skin, and reports no new clinical results.
38 citations
,
July 1998 in “Journal of surgical oncology” This review discusses acquired hypertrichosis lanuginosa, a rare disorder often linked to internal malignancy, and reports no new clinical findings; the authors highlight proposed pathogenic mechanisms for lanugo hair overgrowth.
37 citations
,
December 2014 in “Journal of Biomedical Informatics” This study introduced LabeledIn, a semi-automatic, human-reviewed catalog of drug-disease treatment relationships, highlighting the important role of human input in creating accurate and detailed drug indication resources.