5 citations
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August 2018 in “European Psychiatry” In this large multicenter study, severe hair loss related to psychotropic drug treatment was very rare but occurred more frequently in female patients, with valproic acid showing the highest risk.
April 2026 in “The Journal of Urology” In this large retrospective study, low-dose finasteride for androgenetic alopecia was associated with an increased risk of erectile dysfunction at one and three years among men aged 18-45.
In this large retrospective study, patients using compounded topical finasteride and minoxidil through a telehealth platform for male androgenetic alopecia reported high satisfaction and low incidence of side effects, with no need for higher care or treatment discontinuation due to adverse reactions.
191 citations
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December 2003 in “Journal of Investigative Dermatology” Male pattern baldness is largely genetic, linked to the androgen receptor gene, and may relate to certain health issues.
28 citations
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October 2004 in “Differentiation” This study identified a large deletion in the desmoglein 4 gene as the genetic basis of the Iffa Credo "hairless" rat's skin phenotype, linking it to lanceolate hair mutations.
21 citations
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January 2018 in “Journal of Investigative Dermatology” This study found that large excisional wounds in rats across seven strains do not regenerate new hair follicles, unlike in mice, possibly due to differences in epidermal competence and transcriptional profiles.
10 citations
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July 2021 in “European journal of pharmaceutics and biopharmaceutics” This study reported that larger caffeine nanocrystals, at 694 nm, increased caffeine bioavailability via transfollicular penetration compared to smaller nanocrystals, especially in long-term serum concentration measurements.
2 citations
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May 2018 in “Journal of Investigative Dermatology” This study found that large excisional wounds in mice can regenerate new hair follicles and fat, whereas similar wounds in rats across seven strains failed to do so, highlighting interspecies differences in regenerative capacity.
June 2026 in “Frontiers in Medicine” This study conducted a large-scale comparison using FAERS data to assess the post-marketing safety profiles of spironolactone, eplerenone, and finerenone, finding unique adverse event patterns for each drug and highlighting the need for personalized safety monitoring and further investigation in other pharmacovigilance databases.
This manuscript discusses a large-scale cross-sectional analysis on addressing variance in responses to a set of questions by identifying underlying factors, but specific results are not reported in the abstract.
November 2012 in “Transplantation” This study suggests that large corneal stem cells isolated from the stratum corneum may be capable of covering central wound areas when transplanted onto granulation tissue.
48 citations
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August 1998 in “Journal of the American Academy of Dermatology” This review discusses the structural differences between black and white skin, noting that black skin has more compact stratum corneum, larger melanosomes, and increased transepidermal water loss.
38 citations
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June 2018 in “Archives of Toxicology” This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.
21 citations
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November 2017 in “Livestock science” This study confirms the presence of large structural variations in the genome of Nellore cattle, which may contribute to their environmental adaptation to tropical regions.
19 citations
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November 1985 in “Archives of Dermatology” This case study documented a black male newborn developing large bullae that healed with hypopigmentation, suspecting proteolytic enzymes in keratinocytes caused the collagenolysis responsible for the condition.
8 citations
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June 2014 in “PubMed” Men are more likely to have larger basal cell carcinomas and squamous cell carcinomas, while women have more superficial basal cell carcinomas and tumors on their legs and central face.
5 citations
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May 2004 in “International Journal of Cosmetic Science” This study demonstrated that the large molecule versican plays a critical role in hair induction in dermal papilla cells, with potential implications for developing new hair growth treatments.
3 citations
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April 2023 in “Veterinary sciences” This study found that among Large White × Min pigs, 15 significant copy number variation regions were associated with villi hair traits, and identified candidate genes potentially linked to cold resistance, suggesting implications for breeding cold-resistant pigs.
3 citations
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November 1992 in “The Journal of Dermatologic Surgery and Oncology” This study found that combining a large posterior Z-plasty with staged modified paramedian scalp reductions significantly minimized the "slot" defect scar following scalp reduction surgeries.
2 citations
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May 2025 in “The Journal of Dermatology” This study reported that a large proportion of US adults with physician-diagnosed alopecia areata experience substantial emotional and mental health comorbidities and report significant stigma across all disease severities, yet few are receiving counseling or therapeutic intervention.
2 citations
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July 2022 in “Stem cell research & therapy” This study found that a large number of pelage hair follicle mesenchymal stem cells can be efficiently isolated using two-step Ficoll Density Gradient Sedimentation, promoting hair growth by secreting exosomes in mice.
1 citations
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December 2020 The skin is the body's largest organ, with layers, cells, and structures that protect and support it.
1 citations
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January 2009 in “The Open Dermatology Journal” This case report describes a patient with diffuse large B cell lymphoma who experienced temporary Beau’s lines and onycholysis while undergoing R-CHOP chemotherapy, which resolved two months after treatment ended.
October 2024 in “Journal of the American Society of Nephrology” This study found that in a large cohort of chronic kidney disease patients, nonprogression or regression of the disease was more common than progression or kidney failure, especially with advancing age.
May 2023 in “Cytotherapy” This study found that medium/large extracellular vesicles derived from hair follicle and adipose tissue mesenchymal stromal cells both demonstrated significant neuroprotective and anti-inflammatory effects in cell cultures, highlighting their potential use as biopharmaceuticals for treating neurodegenerative diseases.
January 2023 in “Research Square (Research Square)” This study observed that in a large, diverse US adult population, skin of color was associated with a higher prevalence of alopecia areata, whereas lower prevalence was seen among those with lower education, income, and lacking health insurance.
October 2022 in “Hair Transplantation” This review discusses techniques for repairing large scalp defects, emphasizing the combination of older methods like scalp reduction and tissue expansion with modern hair restoration surgery to achieve satisfactory results, despite challenges like compromised scalp viability due to factors like trauma or radiation.
July 2022 in “International journal of surgery science” This case report details a rare large epidermal cyst over the sacrumcoccygeal region in an elderly patient, which was successfully removed surgically.
March 2003 in “CRC Press eBooks” This article discusses telogen effluvium, a condition where a large number of scalp hairs prematurely enter the shedding phase, and reports no new clinical results; the authors emphasize the range of potential underlying causes.
35 citations
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November 2021 in “Environmental Health” This commentary discusses how environmental epidemiology has largely neglected the impact of racism on health outcomes, suggesting various solutions to better integrate these considerations into research.