Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study observed defects in hair cuticle cross-linking in some, but not all, mouse mutants with sparse or structurally unsound hair.

This article discusses the development and clinical progress of PROTAC technology, particularly focusing on the New Drug Application for vepdegestrant, an estrogen receptor-targeting PROTAC, marking significant advancements in targeted protein degradation therapies.

This study found that VEGF-deficient keratinocytes can form tumors using different aneuploidy and signaling patterns, highlighting VEGF's role beyond angiogenesis in tumor cell growth and survival.

This review discusses case reports of autoimmune diseases following vaccination and the challenges of establishing a clear epidemiological connection, urging further investigation into vaccine-induced autoimmunity.

This study found that small proline-rich proteins modify the biomechanical properties of cornified cell envelopes in rodent forestomachs, potentially affecting the tissue's ability to withstand mechanical stress.

Pax9 is crucial for proper tongue surface development and preventing skin-like changes.

In this study, researchers found that size polymorphisms in certain hKAP1 genes are linked to the hKAP1.1B and hKAP1.3 genes, arising from intragenic deletions and duplications in Japanese and Caucasian populations.

This study observed that PAI-2 is consistently expressed in differentiating cells of murine hair and nail, suggesting it may function as a marker of differentiation and possibly protect against premature cell death.

This review discusses the impact of social media on dermatology, highlighting both the potential benefits for engagement and the risks of spreading misinformation; no clinical results are reported.

In this study, researchers discussed how specific protein interactions in reptile skin allow for the development of protective structures like scales and scutes, which facilitated reptiles' adaptation to terrestrial environments.

This ex vivo study reported that melatonin significantly improved certain aging biomarkers in aged human skin, including reduced mTORC1 activity, increased fibrillin-1, and enhanced collagen and elastic fiber organization, though other key biomarkers remained unchanged.

This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.

This study describes a family with loose anagen hair syndrome associated with macular dystrophy, suggesting this combination may represent a new disease entity among ectodermal dysplasias.

In this study, methanol extract of Cuscuta reflexa leaves significantly reduced blood glucose and improved insulin and liver function in alloxan-induced diabetic rats, indicating potential as an antidiabetic and organ-protective agent.

This review discusses Amphiregulin (AREG) as a potential target for treating fibrotic disorders and cancer, highlighting its role in disease progression and promising results in preclinical studies and early trials.

This study found that regular yoga practice could benefit women with PCOS by improving hormonal balance, mitochondrial health, oxidative stress, and inflammation, while also reducing depression symptoms, suggesting yoga as a supportive therapy for managing PCOS.

This review discusses the role of exosomes in medical aesthetics, focusing on their mechanisms, production, and preservation, but reports no new clinical results and highlights barriers to their widespread application.

In this study, Thy-1 was observed to play a critical role in wound healing in mice, particularly influencing vascular dynamics and blood perfusion during the healing process.

This perspective proposes a new classification system for "superfoods" to better align them with environmental and social sustainability goals, emphasizing plant-based sources over animal-based ones due to lower greenhouse gas emissions and deforestation impacts.

This review discusses treatment options for androgenetic alopecia, with a focus on the better efficacy of oral finasteride and dutasteride over topical minoxidil for male pattern hair loss, but it reports no new clinical results.

This study found that using a combination of ablative CO₂ fractional laser and fetal fibroblast transplantation significantly reduced scarring in mice, with long-term sphere-forming cultured fibroblasts producing scar appearances closest to normal skin.

This study found that complex therapy including biomimetic peptides was effective in treating alopecia compared to a similar treatment without the peptides.

This review discusses various microneedle technologies for long-acting drug delivery, highlighting design considerations and challenges in bringing these minimally invasive devices to market, but it reports no new clinical results.

This narrative review highlights the potential of naturally occurring compounds to target specific molecular pathways and overcome resistance in advanced and recurrent papillary thyroid cancer, offering new therapeutic possibilities beyond traditional treatments like surgery and lifelong hormone replacement.

This study identified genetic variations that could serve as candidate markers for improving body conformation traits in Kazakh fat-tailed coarse-wool sheep through marker-assisted selection.

This review discusses various therapeutic roles of melatonin, particularly its antioxidant and sleep-regulating properties, for skin and scalp conditions, and reports no new clinical results.

This article reviews cell proteomic footprinting technology and its application in improving the authentication and quality control of cell-based immunotherapeutics, without providing new clinical results.

This study produced and characterized four new monoclonal antibodies that specifically recognize differentiation antigens in human hair follicle and epidermal structures.