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The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Targeting colon cancer stem cells might lead to better treatment results.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Nerves are crucial for the regeneration of various body parts in many animals.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.