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Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Targeting NETs may help reduce fibrosis in Crohn's disease.

Collagen makes skin stiff, and preservation methods greatly increase tissue stiffness.

Rapamycin may help treat Leigh syndrome by targeting protein kinase C.

Mitochondrial dysfunction is linked to various skin conditions and could be a target for treatments.

WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.

Claudin-1 is important for the barrier function and growth of hair.

The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.

Microglia, the brain's immune cells, may contribute to Polycystic Ovary Syndrome (PCOS) by altering the female brain's structure and function, with kisspeptin neurons and GABA neurotransmitters also playing a role.

Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Activating β-catenin in mammary cells leads to changes that cause early-stage abnormal growths similar to skin structures.

New hair can grow from large wounds in mice, but less so as they age, involving reprogramming of skin cells and specific molecular pathways.

Hair follicle stem cells help skin heal and grow during stretching.

Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Editing the FGF5 gene in sheep increases fine wool growth.

Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.

Disrupting β-catenin signaling in certain cells causes anorectal malformations.

Keeping β-catenin levels high in mammary cells disrupts their development and branching.

The vitamin D receptor can work without its usual activating molecule.

GDNF helps grow hair and heal skin wounds by acting on hair stem cells.

PRC2 is essential for maintaining intestinal cell balance and aiding regeneration after damage.

Syndecan-1 is essential for maintaining skin fat and preventing cold stress.

The symposium concluded that understanding the molecular mechanisms of skin aging could lead to better clinical practices and treatments.

Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

Two new compounds were found to effectively reduce hair growth in mice.