research Sulfatase Inhibitors: A Patent Review
The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.
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research Differential Impact of Environmental Factors on Systemic and Localized Autoimmunity
Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.
research T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities
An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.
research The Rho Guanosine Nucleotide Exchange Factors Vav2 And Vav3 Modulate Epidermal Stem Cell Function
Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.
research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion
The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.
research Moxibustion Improves Ovarian Function Based on the Regulation of the Androgen Balance
Moxibustion may help improve ovarian function by changing androgen levels.
research Risk Factors, Prevalence, and Diagnosis of Hutchinson-Gilford Syndrome with Special Reference to Case Reports
Hutchinson-Gilford Progeria Syndrome is a rare genetic disorder caused by a specific gene mutation, characterized by aging symptoms and managed by monitoring heart health and using low-dose aspirin.
research Effect of Finasteride Particle Size Reduction on Its Pharmacokinetic, Tissue Distribution, and Cellular Permeation
Smaller finasteride particles increase effectiveness in treating hair loss.
research Co-Opting Developmental Signaling Pathways to Promote Wound Healing
Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.
research Forensics in Dermatology: Part II
Dermatologists play a key role in identifying and documenting signs of abuse and injury for forensic investigations.
research Epidemiological Trends in Alopecia Areata at the Global, Regional, and National Levels
Cases of alopecia areata and its impact on life quality rose globally, but when adjusted for age, the rates decreased, especially in poorer regions.
research Hair Growth Stimulation by a Natural Remedy: Animal Studies
The plant extract remedy Satura® Rosta promotes hair growth and regrowth without negative effects.
research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle
Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
research Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family
L-PGDS has specific binding sites for its functions and could help in drug delivery system design.
research Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development
Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.
research Mediterranean Diet: Fresh Herbs And Fresh Vegetables Decrease The Risk Of Androgenetic Alopecia In Males
Mediterranean diet with fresh herbs and vegetables lowers male hair loss risk.
research Post-Screening Follow-Up of the Finnish Prostate Cancer Screening Trial on Putative Prostate Cancer Risk Factors: Vitamin and Mineral Use, Male Pattern Baldness, Pubertal Development, and Non-Steroidal Anti-Inflammatory Drug Use
Late puberty may slightly lower prostate cancer risk, baldness is not linked to overall risk but less so with aggressive types, ibuprofen use may increase risk, and vitamins show no effect on risk.
research The Cellular Basis of Mechanosensory Merkel-Cell Innervation During Development
BMP signaling is essential for the development of touch domes.
research Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins
Cyclodextrins improve finasteride's solubility and bioavailability for hair loss treatment.
research Secondary Syphilis in HIV-Infected Men Who Have Sex with Men: A Case Report
HIV-infected men who have sex with men are at higher risk for aggressive syphilis, but treatment and tests are effective.
research Pathophysiology and Nutritional Approaches in Polycystic Ovary Syndrome: A Comprehensive Review
Eating a Mediterranean diet and taking certain supplements may improve symptoms of PCOS.
research Development of a Doxazosin and Finasteride Transdermal System for Combination Therapy of Benign Prostatic Hyperplasia
Researchers created a skin patch that delivers two drugs for treating enlarged prostate, which may improve patient use and dosage control.
research Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans
Hair follicles greatly increase caffeine absorption through the skin shortly after it's applied.
research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened
The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.
research Dihydrotestosterone Induces Arterial Stiffening in Female Mice
Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.
research Frizzled Receptors in Development and Disease
Frizzled receptors are essential for various body development processes and maintaining certain body functions.
research The Role of 3Rs in the Age of One Health: Where We Are and Where We’re Going
Innovative methods are reducing animal testing and improving biomedical research.
research Alterations in Transcriptome and Antioxidant Activity of Naturally Aged Mice Exposed to Selenium-Rich Rice
Eating selenium-rich rice improved antioxidant activity and signs of aging in mice.
research Sex Differences in Arterial Hypertension
Women may need different blood pressure guidelines than men for heart disease prevention.
research Bio-Monitoring of Air Quality Using Leaves of Trees and Lichens in Urban Environments
Tree leaves and lichens can effectively indicate air pollution levels in cities.