research Effective Treatment of Alopecia Universalis with Oral Tofacitinib: A Case Report
Oral tofacitinib successfully treated total body hair loss in one patient.
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600-630 / 1000+ results research Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis
The study demonstrated that the transcription regulators YAP and TAZ were essential for maintaining skin homeostasis by promoting the proliferation of basal layer stem/progenitor cells. In both mouse and human skin, YAP and TAZ localized in the nucleus of basal layer cells, regulated by integrin-Src signaling. Deletion of YAP and TAZ in mice resulted in slowed cell proliferation, hair loss, and impaired wound healing, underscoring their role in skin regeneration. The research highlighted the importance of integrin-Src and EGFR-PI3K signaling pathways for YAP nuclear localization, which was crucial for cell cycle progression and growth. Additionally, YAP acted as a sensor of epithelial cell polarity, with its localization influenced by apical-basal polarity signals. These findings provided insights into the molecular mechanisms of skin renewal and the potential impact of YAP and TAZ on skin-related conditions and cancer.
research Fibroblast Growth Factors: Key Players in Regeneration and Tissue Repair
Fibroblast Growth Factors (FGFs) are important for tissue repair and regeneration, influencing cell behavior and other factors involved in healing, and are crucial in processes like wound healing, bone repair, and hair growth.
research A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock
BMAL1 and Period1 genes can influence human hair growth.
research Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress
Syndecan-1 is essential for maintaining skin fat and preventing cold stress.
research The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology
PPARγ is crucial for skin health but can have both beneficial and harmful effects.
research Therapeutic, Prophylactic, and Functional Use of Probiotics: A Current Perspective
Probiotics show promise for health benefits but need more research to understand how they work.
research Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells
Baricitinib reduces inflammation and improves cell health in premature aging cells.
research Lysophospholipid Mediators in Health and Disease
Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.
research Cyclosporine for Moderate-to-Severe Alopecia Areata: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety
Cyclosporine showed some improvement in alopecia areata but results were not statistically significant.
research Efficacy and Skin Toxicity Management with Cetuximab in Metastatic Colorectal Cancer: Outcomes from an Oncologic and Dermatologic Cooperation
Combining irinotecan and cetuximab is effective for some metastatic colorectal cancer patients but often causes manageable skin issues.
research Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction
Stress can cause early aging in certain skin cells, leading to problems with hair growth.
research MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment
MicroRNA-21 could help diagnose and treat skin fibrosis.
research Alopecia Areata: An Autoimmune Disease of Multiple Players
Alopecia areata is an incurable autoimmune condition causing hair loss, with research aiming for better treatments.
research ‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata
Alopecia Areata (AA) causes significant emotional distress, including feelings of embarrassment, depression, and anxiety, and impacts social interactions and daily activities.
research Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation
Fat under the skin releases HGF which helps hair grow and gain color.
research Dermatologic Adverse Events in Pediatric Patients Receiving Targeted Anticancer Therapies: A Pooled Analysis
Targeted anticancer therapies in children often cause skin side effects like rash and dry skin.
research Activation of Androgen Receptor Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation
Breast cancer treatments work better with AR activation, improving results and reducing side effects.
research Dupilumab Therapy for Alopecia Areata in Pediatric Patients with Concomitant Atopic Dermatitis
Dupilumab may help children with alopecia areata and atopic dermatitis regrow hair.
research Follistatin Promotes LIN28B-Mediated Supporting Cell Reprogramming and Hair Cell Regeneration in the Murine Cochlea
Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.
research Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata
Alopecia areata patients, especially women with nail issues or atopic diseases, are at higher risk for other autoimmune diseases.
research Vitamin D and Alopecia Areata: Possible Roles in Pathogenesis and Potential Implications for Therapy
Vitamin D might be involved in the development of alopecia areata and could help in its treatment.
research The Link Between Obesity and the Skin
Obesity is linked to various skin conditions and issues, and losing weight can improve these conditions.
research Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls
Men with androgenetic alopecia have oilier and less hydrated scalps, especially in sensitive areas.
research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
Adding a second method to PROTACs could improve cancer treatment.
research Autophagy: Guardian of Skin Barrier
Autophagy helps keep skin healthy and may improve treatments for skin diseases.
research Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing
Researchers identified five new potential targets for leishmaniasis treatment, suggesting repurposing existing drugs could be effective.
research Myristoleic Acid Promotes Anagen Signaling by Autophagy Through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells
Myristoleic acid helps hair growth by boosting cell growth and recycling processes in hair follicle cells.
research Dupilumab for the Treatment of Alopecia Areata in Children with Atopic Dermatitis
Dupilumab may help treat alopecia areata in children with atopic dermatitis, but it can also cause new hair loss.
research The Need for Speed and Efficiency: A Brief Review of Small Molecule Antivirals for COVID-19
Some small molecule antivirals show promise against COVID-19, but more research is needed to understand and improve them.