April 2019 in “Journal of Investigative Dermatology” Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.
Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.
Dermal stem cells help regenerate hair follicles and heal skin wounds.
6 citations,
December 2019 in “BMC Complementary and Alternative Medicine” Alcohol extract from Vernonia anthelmintica seeds may help treat stress-related hair loss.
April 2019 in “Journal of Investigative Dermatology” Y27632 increases cell growth through EGFR signaling, not ROCK1/2.
Ganoderma lucidum extract may help treat stress-related hair loss.
September 2008 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Loss of Desmocollin 3 in mice causes skin blisters and hair loss.
7 citations,
November 2016 in “Oncotarget” UV exposure reduces Lgr6+ stem cells in mouse skin and they don't significantly contribute to skin cancer development.
4 citations,
August 2022 in “International Journal of Molecular Sciences” Human foreskin does not show aging or reduced cell growth after radiation, and H2A.J is not a good marker for radiation-induced aging.
2 citations,
September 2022 in “Frontiers in Immunology” T-regulatory cells are important for skin health and can affect hair growth and reduce skin inflammation.
July 2024 in “International Journal of Molecular Sciences” RF-based therapies might help treat hair loss.
August 2022 in “Biomedicines” Turning off the Lhx2 gene in mouse embryos leads to slower wound healing and scars.
450 citations,
January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color is determined by melanin produced and transferred in hair follicles.
266 citations,
January 2016 in “Development” YAP and TAZ are crucial for skin cell growth and repair.
245 citations,
October 2015 in “Nature medicine” Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.
224 citations,
February 2013 in “The Journal of clinical investigation/The journal of clinical investigation” ERG increases SOX9, promoting prostate cancer growth and invasion.
182 citations,
May 2003 in “Development” Myc activation reduces skin stem cells by affecting cell adhesion.
176 citations,
February 2006 in “Cancer Research” Patched1 helps prevent tumors by controlling cell growth.
164 citations,
February 2010 in “Journal of Cell Science” Human dermal stem cells can become functional skin pigment cells.
135 citations,
December 2006 in “PLoS Medicine” Hyaluronate fragments can help reverse skin thinning by working with the CD44 receptor.
132 citations,
August 2008 in “Development” Dlx3 is essential for hair growth and regeneration.
124 citations,
January 2012 in “Journal of Allergy and Clinical Immunology” Endocannabinoids help control mast cell activity in human skin.
105 citations,
October 2018 in “Nature” A small group of slow-growing cells causes basal cell carcinoma to return after treatment.
93 citations,
May 2002 in “Journal of Investigative Dermatology” Overexpressing thrombospondin-1 in mice skin prevents UVB-induced skin damage.
88 citations,
August 2014 in “PLOS genetics” Syndecan-1 is essential for maintaining skin fat and preventing cold stress.
85 citations,
April 2012 in “PLOS ONE” Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.
84 citations,
December 2008 in “Developmental biology” Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.
75 citations,
September 2016 in “EMBO journal” PRC2 is essential for maintaining intestinal cell balance and aiding regeneration after damage.
73 citations,
December 2015 in “Nature Genetics” Mutations in TBX3 cause horses to have more even hair color instead of Dun camouflage.
67 citations,
June 2019 in “Proceedings of the National Academy of Sciences” A new 3D culture system helps grow and study mouse skin stem cells for a long time.