14 citations
,
July 2019 in “Journal of Investigative Dermatology” In this study, targeted inactivation of the integrin-linked kinase gene in melanoblasts led to defects in cell migration, proliferation, and ability to populate the skin, implicating an integrin-linked kinase-Rac1 connection in melanocyte function.
13 citations
,
January 2017 in “Molecules” This study reported that compounds isolated from Alpinia zerumbet significantly promoted hair cell growth and exhibited anticancer activity in cell cultures, suggesting potential as treatments for alopecia and cancer.
11 citations
,
September 2019 in “Dermatologic Surgery” This study found that vascular endothelial growth factor may protect hair follicle stem cells from androgen-induced apoptosis in androgenic alopecia patients via the PI3K/Akt pathway.
11 citations
,
October 2007 in “Journal of Investigative Dermatology” Mutations in the Sgk3 gene cause fuzzy hair in mice.
11 citations
,
September 1997 in “Archives of Dermatology” Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.
9 citations
,
April 2006 in “American Journal of Pathology” This study found that mutations in the Sgk3 gene cause defective hair follicle development and altered hair cycling in mice, with variable phenotypic outcomes depending on different dysfunction patterns of the SGK3 protein.
9 citations
,
May 2012 in “PLOS ONE” This study found that integrin-linked kinase is crucial for various epidermal functions, including differentiation and barrier formation, and also plays a previously unreported role in melanocyte development and function.
9 citations
,
February 2001 in “Journal of Dermatological Science” This study found that the expressions of CDK inhibitors p21waf1/cip1 and p27kip1 were higher during the anagen phase compared to telogen, suggesting a role in follicular epithelial cell differentiation.
8 citations
,
July 2024 in “Journal of Advanced Research” In this study, researchers report that CDK inhibitors like palbociclib and ribociclib, initially developed for cancer therapy, show potential in treating neutrophilic inflammation-related conditions such as ARDS and psoriasis, although their clinical repurposing requires further research on safety and dose adjustments.
8 citations
,
April 2013 in “Der Hautarzt” This article reviews common types of acquired alopecia in children that do not involve scalp inflammation or scarring, highlighting alopecia areata and trichotillomania, but reports no new clinical results.
8 citations
,
September 2002 in “Genes to Cells” This study suggests that label-retaining cells in the hair follicle contribute to follicular renewal, indicating a specific role in the hair cycle by proliferating during the late telogen phase.
7 citations
,
December 2023 in “International Journal of Molecular Sciences” This study demonstrated that Forsythiaside A protected against oxidative stress in both cell models and a mouse model of liver damage, suggesting its potential as a liver-protective agent.
7 citations
,
March 2023 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This letter discusses the potential of the Janus kinase 1 inhibitor abrocitinib for treating oral lichen planus but provides no new research findings.
6 citations
,
June 2023 in “Experimental Dermatology” In this study, researchers found that inducing mitophagy can alleviate NLRP3 inflammasome activation in outer root sheath cells under conditions of mitochondrial stress, suggesting that targeting mitophagy and inflammasome interactions may offer new therapeutic approaches for alopecia areata.
6 citations
,
July 2020 in “The Kaohsiung Journal of Medical Sciences” This study observed that radiation exposure in male rats activated hepatic stellate cells and the PI3K/Akt signaling pathway, mediated by TGF-β1, contributing to liver injury, while the use of a signaling pathway inhibitor reduced these effects.
6 citations
,
January 2019 in “International Journal of Medicine in Developing Countries” This study found that premature greying of hair was reported in 42.5% of young adults from King Faisal University, with higher prevalence among females, and noted associations with various health and lifestyle factors.
6 citations
,
January 2016 in “International Journal of Trichology” This case study suggests that patients with acquired progressive kinking of the hair may benefit from finasteride treatment due to an increased risk of developing androgenetic alopecia.
6 citations
,
December 2011 in “Clinical and Experimental Dermatology” A woman developed rare, unexplained curly hair on her scalp and eyelashes.
6 citations
,
May 1997 in “Journal of Contemporary Religion” This paper offers an initial exploration of the Messianic Communities, outlining their origins in the Jesus Movement and their place in American religious history, without reporting new empirical findings.
5 citations
,
October 2022 in “Biology” This study found that CAP1 plays a significant role in reducing ammonium toxicity in Arabidopsis thaliana by promoting shoot growth and maintaining reactive oxygen species homeostasis.
5 citations
,
June 2014 in “Der Hautarzt” This review discusses genetic causes and classification of rare, monogenic forms of alopecia and highlights the role of molecular genetic research in understanding hair loss mechanisms but reports no new clinical results.
4 citations
,
June 2024 in “British Journal of Dermatology” This study found that treatment with EGFR inhibitors or mitogen-activated kinase inhibitors may compromise the immune privilege of human scalp hair follicles, suggesting new directions for managing drug-induced folliculitis.
4 citations
,
February 2019 in “BioMed Research International” In this study, ebastine significantly increased the proliferation of human follicle dermal papilla cells and may contribute to hair regrowth by activating the ERK signaling pathway.
4 citations
,
January 2011 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study demonstrated that vitamin B12 may promote hair growth in vitro by modulating intracellular signaling in the wnt-pathway, suggesting potential benefits for micrograft transplantation.
3 citations
,
September 2024 in “International Journal of Molecular Sciences” This review examines how mathematical modeling of the MAPK pathway, enhanced by single-cell proteomic data, improves understanding of regulatory mechanisms, predicts system behavior, and guides experimental research, emphasizing recent developments in modeling and inference.
3 citations
,
March 2021 in “Indonesia Medicus Veterinus” This case report describes successful treatment of anaplasmosis in a Kintamani mix dog with doxycycline, ivermectin, vetadryl, and Livron b-plex, leading to improved activity, hair growth, appetite, and tick eradication.
3 citations
,
July 2020 in “Frontiers in Cell and Developmental Biology” This study found that the purified compound VB1 from Vitex negundo seeds may reduce UVA-induced skin aging by targeting MAPK1 and demonstrated its potential in mice.
3 citations
,
January 2014 Collagen XVIII and Bmx tyrosine kinase are important for hair growth and skin cancer development.
2 citations
,
November 2025 in “PLoS ONE” This study found that CDK4/6 inhibitors for HR+/HER2- advanced breast cancer are linked to typical adverse events such as fatigue and neutropenia, while also identifying unexpected reactions, highlighting potential safety concerns in their real-world use.
2 citations
,
January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that low temperatures and nitrogen deficiency trigger root hair elongation through a molecular mechanism involving the receptor kinase FERONIA and the TOR Complex 1.